Anterior Prostate Lobe
Anterior Prostate Lobe - Related Videos
02:34
Individual Lobe Extraction from Prostate: A Technique to Harvest Individual Prostate Lobes from Mouse Prostate
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2023
This video describes a technique to harvest individual lobes from the prostate gland of a mouse model. Individual lobes can then be used for histological analysis and cancer research.
04:40
Modeling Prostate Cancer in Genetically-engineered Mouse Models: A CRISPR/Cas9-mediated Localized Gene Editing Technique in Mouse Anterior Prostate Lobe Cells
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2023
This video describes a method for editing specific genes in prostate gland cells using an adenovirus-based delivery system. The approach allows for orthotopic and localized alteration of gene expression utilizing CRISPR technology to develop novel mouse models for prostate cancer.
06:11
Laparoscopic Anatomical Resection of the Right Anterior Lobe Based on the Laennec Capsule Technique
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Cited by 1 •
2025
This protocol describes a laparoscopic anatomical right anterior sectionectomy utilizing the Laennec capsule concept, combined with comprehensive preoperative therapy. The approach enables precise tumor resection in hepatocellular carcinoma (HCC) cases closely associated with major vascular structures, improving surgical safety, efficacy, and long-term patient outcomes.
05:07
Intra-prostatic Injection of Cancer Cells: A Technique to Deliver Cancer Cells for Establishing Orthotopic Prostate Cancer Mouse Model
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2023
In this video, we demonstrate the procedure for administering intra-prostatic injection of prostate cancer cells into a mouse model. Orthotopic murine models can be used to study the disease origin and response to treatment therapies in a non-invasive and clinically relevant environment.
08:49
Murine Prostate Micro-dissection and Surgical Castration
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Cited by 23 •
2016
This manuscript describes the protocols for prostate micro-dissection and surgical castration in the laboratory mouse. We also depict representative results produced by these protocols. Finally, we discuss the advantages and utilization of these protocols.
FAQs
Androgen receptor signaling helps regulate tissue maintenance, secretory activity, and growth in the anterior prostate lobe. Its effects depend not only on hormone-responsive epithelial cells but also on interactions with surrounding stromal cells. Examining these coordinated responses allows researchers to distinguish normal tissue regulation from changes associated with epithelial transformation or altered growth.
Epithelial and stromal cells provide complementary information about prostate biology. Epithelial cells reflect changes in glandular function and transformation, whereas stromal interactions help reveal how the surrounding microenvironment influences tissue maintenance and growth. Considering both compartments gives cancer researchers a broader view of how altered signaling may affect the progression of prostate disease.
Studies can examine prostate development, tumor initiation, epithelial transformation, and responses to hormone-directed interventions. These outcomes connect tissue-level observations with experimental changes in hormonal or genetic conditions. Because the lobe has defined anatomical and histological features, researchers can compare disease-related alterations across experimental groups while retaining a consistent tissue context.
Evaluation typically centers on examining the lobe in experimental animals and assessing measurable histological features. Researchers can then compare tissue organization and disease-related changes across different experimental conditions. This approach links anatomical observations with questions about development, tumor initiation, epithelial transformation, or treatment response without relying on a single biological measurement.
Genetically engineered animals are useful when researchers need to assess how defined genetic changes influence prostate development or tumor initiation. Examination of the anterior prostate lobe provides an organized tissue setting for observing resulting epithelial and stromal changes. These comparisons can help connect altered biology with the appearance of cancer-related tissue features.
The model supports evaluation of hormone-directed interventions by allowing researchers to examine tissue responses within an androgen receptor-regulated environment. Changes in secretory activity, growth, tissue maintenance, or histological appearance can be considered across experimental conditions. This provides a basis for comparing how interventions affect normal prostate biology and cancer-related alterations in the same anatomical region.