Simple Cubic

Simple cubic is a crystal lattice in which identical atoms occupy the eight corners of a cubic unit cell, making it a fundamental model for describing solid-state structure in chemistry. Because each corner atom is shared among eight neighboring cells, the unit cell contains one net atom; atoms touch along the cube edge, giving a coordination number of six and a packing efficiency of about 52%. This arrangement is less densely packed than body-centered or face-centered cubic structures, but it provides a clear basis for relating atomic geometry to density, bonding, and material properties, including the structure of alpha-poloni​​um.

Simple Cubic - Related Videos

Research

JoVE Journal - Biology

CUBIC Protocol Visualizes Protein Expression at Single Cell Resolution in Whole Mount Skin Preparations

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Cited by 9 •

2016

This report describes a CUBIC protocol to clarify full thickness mouse skin biopsies, and visualize protein expression patterns, proliferating cells, and sebocytes at the single cell resolution in 3D. This method enables accurate assessment of skin anatomy and pathology, and of abnormal epidermal phenotypes in genetically modified mouse lines.

Whole-Kidney Three-Dimensional Staining with CUBIC

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Cited by 5 •

2022

The present protocol describes a tissue clearing method and whole-mount immunofluorescent staining for three-dimensional (3D) kidney imaging. This technique can offer macroscopic perspectives in kidney pathology, leading to new biological discoveries.

Imaging Serotonergic Fibers in the Mouse Spinal Cord Using the CLARITY/CUBIC Technique

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Cited by 13 •

2016

Supraspinal projections are important for pain perception and other behaviors, and serotonergic fibers are one of these fiber systems. The present study focused on the application of the combined CLARITY/CUBIC protocol to the mouse spinal cord in order to investigate the termination of these serotonergic fibers.

Research

JoVE Journal - Biochemistry
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Preparation and Delivery of Protein Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography

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Cited by 20 •

2016

We describe procedures for the preparation and delivery of membrane protein microcrystals in lipidic cubic phase for serial crystallography at X-ray free-electron lasers and synchrotron sources. These protocols can also be applied for incorporation and delivery of soluble protein microcrystals, leading to substantially reduced sample consumption compared to liquid injection.

CUBIC-based Protein Expression Visualization: A Procedure for Visualizing Protein Expression in Full Thickness Mouse Skin Biopsies

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2023

This video describes the CUBIC-based visualization technique, a tissue clearing-dependent imaging technique for visual assessment of protein expression in whole-mount skin biopsies at single-cell resolution in 3D. This technically simple protocol allows the visualization of skin proteins without preparing skin sections.

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