Heart Metabolism
Heart Metabolism - Related Videos
07:27
Implantation of Total Artificial Heart in Congenital Heart Disease
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Cited by 40 •
2014
This is a case report of a patient with congenitally corrected transposition of the great arteries (CCTGA) who received a total artificial heart (TAH) as a bridge to heart transplant. The TAH was successfully implanted with modifications to accommodate the patient's congenitally malformed heart.
06:31
In Vitro Culture of Epicardial Cells From Mouse Embryonic Heart
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Cited by 13 •
2016
The epicardium is an essential source of multipotent cardiovascular progenitor cells and paracrine factors that are required for cardiovascular development and regeneration. We describe here a method to culture mouse embryonic epicardial cells.
05:41
Metabolic Profile Analysis of Zebrafish Embryos
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Cited by 42 •
2013
Zebrafish represent a powerful vertebrate model that has been under-utilised for metabolic studies. Here we describe a rapid way to measure the in vivo metabolic profile of developing zebrafish that allows the comparison of different mitochondrial function parameters between genetically or pharmacologically manipulated embryos, thereby increasing the applicability of this organism.
00:52
What is Metabolism?
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2019
Overview Metabolism represents all of the chemical activity in a cell, including reactions that build molecules (anabolism) and those that break molecules down (catabolism). Anabolic reactions require energy, whereas catabolic reactions provide it. Thus, metabolism describes how cells transform energy through a variety of chemical reactions, which are often made more efficient with the help of enzymes. Metabolism Is the Sum of All of the Chemical Reactions That Take Place in an Organism
06:59
Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
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Cited by 7 •
2016
The goal of this protocol is to present a standard method to perform intravenous glucose tolerance tests (IVGTTs) to assess glycemic control in nonhuman primates and assess their metabolic status from healthy to dysmetabolic.
FAQs
As mitochondria mature, oxidative phosphorylation contributes increasingly to ATP production alongside glycolysis. This change alters how developing cardiomyocytes meet the energy demands of contraction and growth. Because energy production is linked to cellular behavior, the transition can influence cardiomyocyte maturation and the structural remodeling that shapes the developing heart.
Glucose and fatty acids serve as important substrates whose use changes during cardiac development. Cardiomyocytes adjust their relative reliance on these fuels as mitochondrial function develops and oxidative phosphorylation becomes more prominent. Tracking this substrate transition helps connect nutrient use with energy production, cell maturation, and the changing functional demands of the developing heart.
Mitochondrial maturation marks a major metabolic transition in developing cardiac cells. As mitochondria become more capable of supporting oxidative phosphorylation, ATP production increasingly complements glycolysis. This shift provides a metabolic context for cardiomyocyte maturation and structural remodeling, making mitochondrial development relevant when investigating how normal cardiac form and function emerge.
Disrupted metabolic transitions may interfere with the coordination between energy production, cardiomyocyte growth, maturation, and structural remodeling. The overview identifies congenital heart defects and cardiomyopathies as conditions relevant to this relationship. Studying metabolic changes during development can therefore help researchers examine whether abnormal substrate use or mitochondrial progression accompanies impaired cardiac formation or function.
Developmental studies can follow how cardiomyocytes change their use of glucose and fatty acids while mitochondria mature and oxidative phosphorylation increases. Interpreting these metabolic patterns alongside proliferation, maturation, and structural remodeling connects biochemical changes with developmental outcomes. This approach supports developmental modeling by showing how cellular energy programs relate to cardiac formation.
Metabolic transitions provide a framework for evaluating whether engineered or modeled cardiac cells display developmentally relevant behavior. Comparing glycolysis, substrate use, mitochondrial maturation, and oxidative phosphorylation can help assess cellular maturation and organization. The same perspective is relevant to impaired regeneration, because metabolic regulation may influence how effectively cardiac cells develop or restore tissue properties.