Gluten-free Diet
Gluten-free Diet - Related Videos
06:19
Testing Nicotine Tolerance in Aphids Using an Artificial Diet Experiment
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Cited by 5 •
2008
In this video and assay is demonstrated that tests the tolerance of nicotine to two types of aphids one that infests tobacco plants in the field and one that does not.
06:51
Film Extrusion of Crambe abyssinica/Wheat Gluten Blends
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Cited by 3 •
2017
The side stream from plant oil production of Crambe abyssinica has limited value. The purpose of this study was to find methods for extruding materials based on this side stream, demonstrating that products with a higher value can be produced. The extrudates were found to have promising properties.
08:28
High Fat Diet Feeding and High Throughput Triacylglyceride Assay in Drosophila Melanogaster
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Cited by 29 •
2017
This is a high fat diet feeding protocol to induce obesity in Drosophila, a model for understanding fundamental molecular mechanisms implicated in lipotoxicity. It also provides a high throughput triacylglyceride assay for measuring fat accumulation in Drosophila and potentially other (insect) models under various dietary, environmental, genetic or physiological conditions.
07:27
The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury
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Cited by 14 •
2017
Here we describe a common method to induce chronic liver injury in mice by feeding of a choline-deficient and ethionine-supplemented (CDE) diet. We demonstrate health monitoring, liver perfusion, isolation, and preservation. A time course of six weeks can inform about liver injury, pathohistology, fibrosis, inflammatory, and liver progenitor cell responses.
09:10
Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
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Cited by 42 •
2019
This protocol describes the use of a highly palatable, western-style cafeteria diet to model overeating and obesity in rodents. Here, we provide a detailed outline of food selection, preparation and measurement, and explain methodological factors that assist in generating a robust and reproducible phenotype.
FAQs
In genetically susceptible individuals, gluten-derived peptides activate immune responses within the intestine. This activation produces inflammation that damages the small-intestinal villi, the structures responsible for absorbing nutrients. The mechanism connects a dietary antigen with localized mucosal injury, making celiac disease a useful example of how antigen recognition can produce tissue-specific immune pathology.
Genetic susceptibility helps determine whether gluten-derived peptides provoke the intestinal immune response associated with celiac disease. The same dietary exposure therefore does not produce identical consequences in every individual. This distinction is important in immunology because it illustrates how host factors shape antigen-triggered inflammation and the development of immune-mediated disease.
Inflammation-related injury to the small-intestinal villi compromises the structures involved in nutrient absorption. As the immune-mediated damage decreases, removing gluten can support recovery of the intestinal lining and restoration of absorption. This relationship explains why the diet can influence both gastrointestinal symptoms and the nutritional consequences associated with celiac disease.
A gluten-free diet provides a way to examine how removing an antigenic dietary component changes intestinal inflammation and tissue injury. In immunology research, investigators can relate gluten exposure or removal to mucosal barrier function, villous condition, and nutrient absorption. This approach helps connect dietary factors with immune-mediated changes at the intestinal surface.
Research can assess several linked outcomes after gluten removal, including reduction of immune-mediated intestinal inflammation, improvement in gastrointestinal symptoms, and restoration of nutrient absorption. Examining these outcomes together helps distinguish symptomatic change from underlying tissue recovery. It also shows how a dietary intervention can affect both clinical features and intestinal physiology.
The diet offers a model for studying antigen-triggered intestinal inflammation, mucosal barrier function, and the relationship between dietary components and immune-mediated disease. Although the central process concerns immune injury rather than an infectious agent, it is relevant to infection research because it focuses on intestinal defenses and how the mucosal environment responds to external exposures.