Helminth Infection Model
Helminth Infection Model - Related Videos
09:58
Using Eggs from Schistosoma mansoni as an In vivo Model of Helminth-induced Lung Inflammation
0 Views •
Cited by 14 •
2012
Schistosoma mansoni eggs are potent stimulators of the T helper type 2 (Th2) immune response, characteristic of parasite infection, asthma and allergic inflammation. This protocol utilizes S. mansoni egg injection to generate a CD4 Th2 cytokine-induced inflammatory response in the lung, characterized by lung granuloma formation around the egg, eosinophilia and macrophage alternative activation.
10:57
Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
0 Views •
Cited by 59 •
2012
Chronic infection with soil-transmitted helminths (STHs) causes malabsorption, stunting, and wasting in the growing child. Hence, it is plausible that these infections also reduce the physical fitness of children. Here, we visualize two techniques for the diagnosis of STHs and the 20-meter shuttle run test for assessing children's physical fitness.
09:37
Helminth Collection and Identification from Wildlife
0 Views •
Cited by 51 •
2013
Wild animals are commonly parasitized by a wide range of helminths. The four major types of helminths are “roundworms” (nematodes), “thorny-headed worms” (acanthocephalans), “flukes” (trematodes), and “tapeworms” (cestodes). Here we describe how helminths are collected from a vertebrate animal and how they are preserved and taxonomically...
12:30
Use of Galleria mellonella as a Model Organism to Study Legionella pneumophila Infection
0 Views •
Cited by 108 •
2013
The larva of the wax moth Galleria mellonella was recently established as an in vivo model to study Legionella pneumophila infection. Here, we demonstrate fundamental techniques to characterize the pathogenesis of Legionella in the larvae, including inoculation, measurement of bacterial virulence and replication as well as extraction and analysis of infected hemocytes.
07:02
Animal Model of Implant-Associated Infections in Mice
0 Views •
2025
The present protocol describes a mouse model employing subcutaneous dorsal implantation to investigate implant-associated infections, enabling comprehensive investigation of pathophysiological mechanisms and supporting the development of diagnostic criteria with targeted therapeutic strategies.
FAQs
Type 2 immunity provides a central framework for examining host responses to helminths. Exposure to parasites or their antigens can activate innate and adaptive pathways associated with eosinophils and antibody production. Studying these responses helps researchers relate immune activation to host resistance, parasite persistence, tissue effects, and broader patterns of immune regulation.
Eosinophils and antibodies serve as important readouts of the host response to helminth exposure. Their presence reflects activation of immune pathways commonly associated with type 2 immunity, while changes in these responses can be examined alongside parasite development and host resistance. This combination helps connect immune activity with infection outcomes.
Helminths may alter host signaling in ways that support their persistence, making parasite effects on immune regulation an important research focus. A model can examine how these signaling changes relate to immune responses, tissue damage, and continued parasite development. This perspective helps distinguish protective host reactions from processes that may favor ongoing infection.
Animal, cellular, and molecular models provide different levels of information about the same host-parasite interaction. Animal systems allow examination of parasite development, tissue damage, and resistance, whereas cellular and molecular approaches can investigate immune pathways and signaling. Using these complementary systems helps connect organism-level outcomes with specific mechanisms of immune modulation.
Researchers can assess parasite development, tissue damage, immune regulation, and host resistance as distinct but related outcomes. They can also monitor type 2 immune activity, eosinophils, antibody production, and changes in host signaling. Examining these features together provides a broader picture of how infection progresses and how the host responds.
These models support evaluation of vaccines, antiparasitic treatments, and immunotherapies by showing how interventions affect parasite development and host immune responses. They also provide context for studying helminth-associated immune modulation in allergies, inflammation, and other infectious diseases. Consequently, the models connect infection biology with therapeutic and immunological research questions.