Aortic Root Lesions
Aortic Root Lesions - Related Videos
12:17
Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
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Cited by 4 •
2017
Full-root aortic valve replacement by stentless aortic xenograft is a viable option in patients with small aortic roots. We describe, a technique for the full-root implantation of stentless aortic xenografts, with emphasis on the management of the proximal suture line and coronary anastomoses, and discuss its limitations and alternative options.
06:43
Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
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Cited by 51 •
2013
We describe procedures to quantify and characterize atherosclerotic lesions in mouse models using precision sectioning of the aortic sinus and ascending aorta combined with histochemical and immunohistochemical analysis.
07:49
Isolation and Analysis of Aortic Arch and Root Lesions in an Atherosclerotic Mouse Model
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2025
This protocol provides a comprehensive methodology for the quantitative analysis of atherosclerotic plaques to facilitate more in-depth research into the mechanisms and progression of atherosclerosis.
14:14
Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
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2017
Valve-sparing aortic root replacement has the advantage of preserving the patient's own aortic valve. The complexity of the reported techniques to date restricts their use to a limited number of cardiac surgeons. This protocol describes step-by-step a standardized technique reproducible by a greater number of cardiac surgeons.
09:12
Aortic Ring Assay
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Cited by 42 •
2009
Angiogenesis, the sprouting of blood vessels from pre-existing vasculature, is associated with both natural and pathological processes. Here we demonstrate an aortic ring assay that allows angiogenic potentiators and inhibitors to be directly added to aortic rings in culture. Sprouting and neovessel outgrowth can be determined by inspecting the aortic rings over a period of 6-12 days.
FAQs
Expansion can change the normal relationship between the aortic root, aortic valve, and coronary artery origins. The altered geometry may prevent the valve from closing normally, allowing impaired valve function, or may interfere with coronary blood flow. These effects make assessment of both root dimensions and nearby structures important when evaluating the clinical significance of a lesion.
Wall weakening may reflect congenital malformation, inherited connective-tissue disorders, inflammation, infection, trauma, or prolonged hemodynamic stress. These different causes can promote structural remodeling and loss of wall integrity. As damage progresses, the affected segment may dilate or develop dissection, and severe loss of strength can increase the possibility of rupture.
They represent different forms or stages of structural failure rather than interchangeable findings. Dilation reflects enlargement of the affected segment, dissection reflects separation within the aortic wall, and rupture reflects a breach that allows blood to escape. Distinguishing these outcomes helps clinicians judge severity, monitor progression, and determine whether urgent intervention or continued assessment is appropriate.
Evaluation combines physical assessment with imaging that shows the root and its relationships to adjacent structures. Echocardiography can assess the aortic root and valve, while computed tomography and magnetic resonance imaging help define anatomy and wall changes. Using these findings together supports risk assessment, surveillance planning, medical management, and preparation for possible repair.
Imaging helps define the lesion's anatomy, including changes in diameter, wall integrity, and the relationship to the aortic valve and coronary artery origins. Echocardiography, computed tomography, and magnetic resonance imaging provide complementary ways to characterize these features. The resulting anatomical information supports clinical decisions about risk, follow-up, and surgical planning.
Surveillance may be used when clinical evaluation and imaging identify a lesion that requires ongoing observation rather than immediate repair. Follow-up allows clinicians to reassess anatomy and risk over time, particularly when dilation or wall changes could progress. Surveillance is part of a broader strategy that may also include medical management and escalation to repair when indicated.
Identifying the likely cause provides context for interpreting the lesion and its potential behavior. Congenital abnormalities, inherited connective-tissue disorders, inflammation, infection, trauma, and chronic hemodynamic stress can all produce structural changes, but they do so through different pathways. Linking the lesion to its cause supports more informed risk assessment, monitoring, and treatment planning.
Surgical planning becomes important when anatomical changes create substantial risk or threaten nearby structures. Detailed assessment of the root, aortic wall, valve, and coronary origins helps define the problem before repair. Timely planning can support intervention before catastrophic progression, while also allowing clinicians to coordinate management for lesions associated with dissection, rupture, impaired valve closure, or reduced coronary blood flow.