Cardiac Synchronicity Assessment
Cardiac Synchronicity Assessment - Related Videos
09:02
AC Synchronous Machine Synchronization
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2023
Source: Ali Bazzi, Department of Electrical Engineering, University of Connecticut, Storrs, CT. Three-phase wound-rotor synchronous generators are the main source of electrical power worldwide. They require a prime mover and an exciter in order to generate power. The prime mover can be a turbine spun by fluid (gas or liquid), thus the sources of the fluid can be water running off a dam through a long nozzle, steam from water evaporated using burned coal, etc. Most power plants including coal,...
11:10
Respirometric Oxidative Phosphorylation Assessment in Saponin-permeabilized Cardiac Fibers
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Cited by 32 •
2011
Saponin-permeabilized fiber preparation in conjunction with respirometric oxidative phosphorylation analysis provides integrative assessment of mitochondrial function. Mitochondrial respiration in physiological and pathological states can reflect various regulatory influences including mitochondrial interactions, morphology and biochemistry.
11:19
AC Synchronous Machine Characterization
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2023
Source: Ali Bazzi, Department of Electrical Engineering, University of Connecticut, Storrs, CT. Three-phase wound-rotor synchronous motors are less popular than permanent magnet rotor synchronous motors due to the brushes required for the rotor field. Synchronous generators are much more common and available in most existing power plants, as they have excellent frequency and voltage regulation. Synchronous motors have the advantage of almost 0% speed regulation due to the fact that the rotor...
05:04
In vitro Assessment of Cardiac Reprogramming by Measuring Cardiac Specific Calcium Flux with a GCaMP3 Reporter
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Cited by 4 •
2022
We describe here, the establishment and application of an Tg(Myh6-cre)1Jmk/J /Gt(ROSA)26Sortm38(CAG-GCaMP3)Hze/J (referred to as αMHC-Cre/Rosa26A-Flox-Stop-Flox-GCaMP3 below) mouse reporter line for cardiac reprogramming assessment. Neonatal cardiac fibroblasts (NCFs) isolated from the mouse strain are converted into induced cardiomyocytes (iCMs), allowing for convenient and efficient evaluation of reprogramming efficiency and functional maturation of iCMs via calcium (Ca2+) flux.
11:38
Assessment of Cardiac Function and Energetics in Isolated Mouse Hearts Using 31P NMR Spectroscopy
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Cited by 36 •
2010
Langendorff-mode isolated heart perfusion, in conjunction with 31P NMR spectroscopy, combines the fields of biochemistry and physiology into one experiment. The protocol allows for the dynamic measurement of high energy phosphate content and turnover in the heart while concurrently monitoring physiologic function. When performed correctly, this is a valuable technique in the assessment of cardiac energetics.
FAQs
Electrical and mechanical measurements capture different stages of cardiac activity. Electrocardiography records activation, while echocardiography, tissue Doppler, and strain imaging assess contraction. Comparing them can reveal whether a delayed contraction follows delayed electrical activation or reflects altered mechanical timing. This distinction helps characterize the source and significance of dyssynchrony.
Measurements of timing between ventricular segments show whether contraction occurs in a coordinated sequence or with regional delays. These delays may be examined alongside electrical activation to distinguish conduction-related timing differences from mechanical contraction differences. That comparison is clinically relevant when characterizing heart failure and considering whether resynchronization treatment could be evaluated.
Combining modalities provides complementary information rather than relying on a single signal. Electrocardiography indicates when electrical activation occurs, whereas imaging shows how myocardial regions respond mechanically. Agreement or mismatch between these observations can clarify the relationship between activation and contraction. That relationship supports more complete characterization of ventricular coordination in clinical assessment and research.
A typical assessment begins with electrical recording through electrocardiography, followed or paired with cardiac imaging. Echocardiography, tissue Doppler, or strain imaging can evaluate regional contraction and timing. Investigators then compare measurements across ventricular segments and between activation and contraction to identify relevant delays systematically and support interpretation.
In heart failure, cardiac synchronicity assessment helps characterize dyssynchrony and evaluate patients being considered for cardiac resynchronization therapy. Baseline measurements can document the timing relationship among ventricular regions, while repeat assessments may show whether treatment-related changes improve coordinated activation or contraction. This makes the assessment relevant to clinical evaluation and monitoring.
Beyond individual patient evaluation, standardized measurements can support studies of cardiac mechanics, disease progression, and therapies intended to improve coordinated pumping. Consistent timing measurements allow investigators to compare electrical and mechanical findings across assessments and examine treatment-related changes. Its value therefore extends from clinical characterization to structured research outcomes.