Lung Volume Measurement
Lung Volume Measurement - Related Videos
09:49
Measurement of the Pressure-volume Curve in Mouse Lungs
0 Views •
Cited by 47 •
2015
Here we present a protocol to simply and reliably measure the lung pressure-volume curve in mice, showing that it is sufficiently sensitive to detect phenotypic parenchymal changes in two common lung pathologies, pulmonary fibrosis and emphysema. This metric provides a means to quantify the lung’s structural changes with developing pathology.
05:35
Lung Instillation and Fixation: Introducing Liquid into the Trachea and Fixing Lungs to Measure the Fixed Lung Volume
0 Views •
2023
This video describes a simple and reliable method of introducing liquid into the trachea for lung instillation, fixation, and lung volume measurement.
11:26
Real-time X-ray Imaging of Lung Fluid Volumes in Neonatal Mouse Lung
0 Views •
Cited by 1 •
2016
We present a protocol to assess the rate of alveolar fluid clearance or pulmonary edema in neonatal mouse lung using X-ray imaging technology.
09:15
Measuring Pressure Volume Loops in the Mouse
0 Views •
Cited by 16 •
2016
This manuscript describes a detailed protocol for the collection of pressure-volume data from the mouse.
08:51
Understanding Concentration and Measuring Volumes
0 Views •
2023
Solutions are utilized to some degree in almost all biological research applications. Therefore understanding how to measure and manipulate them is imperative to any experiment. In this video, concepts in preparing solutions are introduced. Solutions consist of a solute dissolved in solvent to yield a homogeneous mixture of molecular substances. Solutions are generally identified by their components and corresponding concentrations. Concentrated solutions are diluted through various...
FAQs
Spirometry follows airflow and exhaled volume during controlled breathing maneuvers, whereas body plethysmography uses pressure changes produced while a person breathes inside an enclosed chamber. This distinction allows the two approaches to provide complementary information: spirometry describes how air moves out, while plethysmography estimates the total amount of air the lungs can contain, including air that remains after exhalation.
Total lung capacity indicates the maximum volume the lungs can contain, while residual volume reflects air retained after exhalation. Measuring these quantities adds information that cannot be obtained from exhaled volume alone. Their inclusion helps clinicians assess how fully the lungs expand and empty, which is important when investigating abnormal respiratory function or unexplained breathlessness.
The pattern of measured airflow and lung volumes helps separate obstructive from restrictive respiratory disease. Obstructive conditions are evaluated in relation to difficulty moving air out, whereas restrictive conditions are considered in relation to reduced ability of the lungs to expand. Using the measurements together provides a broader physiological picture than examining airflow or volume in isolation.
A person performs controlled breathing maneuvers while the system records airflow and exhaled volume for spirometry. When body plethysmography is needed, the person breathes inside an enclosed chamber so the equipment can detect pressure changes and estimate total lung capacity and residual volume. The resulting measurements are then considered as indicators of how effectively the lungs expand and empty.
Clinicians may request these measurements to investigate unexplained breathlessness, distinguish obstructive from restrictive lung disease, or monitor changes in respiratory disease over time. Testing can also show whether lung function changes after treatment. By quantifying expansion and emptying, the results support a more structured assessment than symptoms alone and can help follow a patient's respiratory status.
The measurements support preoperative evaluation by providing information about respiratory function before an operation. They also contribute to physiological research, where quantified lung expansion, emptying, and retained air help investigators characterize breathing performance. In clinical care, repeated assessments can document disease progression or treatment response, making the technique useful for both decision-making and longitudinal monitoring.