Pulmonary Pathology
Pulmonary Pathology - Related Videos
08:17
Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
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Cited by 8 •
2017
The following protocol describes the methodology for the acquisition and analysis of echocardiographic images used to obtain the Left Atrial Volume (LAV), Aorta (Ao) diameter, and Pulmonary Artery (PA) diameter in mice. This technique is a non-invasive, non-terminal procedure that allows assessment of the cardiopulmonary function.
05:15
Noninvasive Intratracheal Intubation to Study the Pathology and Physiology of Mouse Lung
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Cited by 22 •
2013
The use of a model that mimics the condition of lung diseases in humans is critical for studying the pathophysiology and/or etiology of a particular disease and for developing therapeutic intervention. Here a noninvasive intratracheal intubation method that can directly deliver exogenous materials to mouse lungs is presented.
14:21
Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation
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Cited by 21 •
2013
A method to image ex vivo pulmonary resection specimens with optical frequency domain imaging (OFDI) and obtain precise correlation to histology is described, which is essential to developing specific OFDI interpretation criteria for pulmonary pathology. This method is applicable to other tissue types and imaging techniques to obtain precise imaging to histology correlation for accurate image interpretation and assessment. Imaging criteria established with this technique would then be...
06:59
Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis
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2025
Pulmonary vein stenosis (PVS) is a life-threatening complication of fibrosing mediastinitis (FM), with a poor prognosis if not properly treated. Currently, catheter-based endovascular angioplasty is a promising therapeutic strategy for FM-associated PVS. This protocol primarily outlines a stepwise approach to the transcatheter procedure for FM-associated PVS.
08:29
Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
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Cited by 7 •
2016
Organized brain cutting procedures are necessary to correlate specific neuropsychiatric phenomena with definitive neuropathologic diagnoses. Brain cuttings are performed differently based on various clinico-academic contingencies. This protocol describes a symmetric bihemispheric brain cutting procedure to investigate hemispheric differences in human brain pathologies and to maximize current and future biomolecular/neuroimaging techniques.
FAQs
The key interpretive step is linking an observed structural or cellular abnormality to altered respiratory function and the patient’s symptoms. Inflammation, infection, fibrosis, vascular injury, and neoplasia represent different disease processes that can disrupt lung or pleural architecture in distinct ways. This structure-function connection helps clinicians interpret findings rather than treating an isolated microscopic change as the diagnosis.
These approaches provide complementary views of the same disease process. Gross examination addresses overall structural change, microscopy examines tissue and cellular abnormalities, cytology focuses on sampled cells, and molecular testing adds information about molecular alterations. Using more than one level supports identification and classification of pulmonary disease by connecting visible, cellular, and molecular findings.
Classification is clinically consequential because similar respiratory symptoms can arise from different processes, including inflammation, infection, fibrosis, vascular injury, or neoplasia. Distinguishing these patterns supports more precise diagnosis, helps estimate prognosis, and can guide treatment selection. In lung cancer and interstitial lung disease, classification also helps organize pathological findings alongside clinical and imaging information.
A basic assessment can proceed from examining a specimen’s gross appearance to evaluating tissue and cells by microscopy or cytology, followed by molecular testing when that level of information is relevant. The observations are then interpreted with imaging and clinical data. This layered process connects laboratory findings to the patient’s disease context and supports a more complete assessment.
Pathological findings gain clinical meaning when compared with imaging and patient information. Correlation helps determine whether the examined abnormality fits the broader respiratory disease rather than being interpreted in isolation. This integrated view supports diagnosis and can contribute to prognosis and treatment decisions, while also providing a stronger basis for studying how structural changes relate to clinical presentation.
Pulmonary pathology contributes to research by connecting disease mechanisms with observable tissue and cellular abnormalities. Studying inflammation, infection, fibrosis, vascular injury, and neoplasia through pathological methods can clarify how respiratory diseases develop and differ. When these findings are combined with clinical and imaging data, they support investigation of targeted therapies and improve understanding of disease-related outcomes.