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Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens

Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation

Article DOI: 10.3791/3855-v 14:21 min January 22nd, 2013
January 22nd, 2013



A method to image ex vivo pulmonary resection specimens with optical frequency domain imaging (OFDI) and obtain precise correlation to histology is described, which is essential to developing specific OFDI interpretation criteria for pulmonary pathology. This method is applicable to other tissue types and imaging techniques to obtain precise imaging to histology correlation for accurate image interpretation and assessment. Imaging criteria established with this technique would then be applicable to image assessment in future in vivo studies.


Optical Frequency Domain Imaging Ex Vivo Pulmonary Resection Specimens Image To Histopathology Correlation Lung Cancer Squamous Cell Small Cell Adenocarcinomas Radiological Resolution Bronchoscopic Limitations Histology Biopsies High-resolution Imaging Modalities Optical Frequency Domain Imaging (OFDI) 3-dimensional Views Coronary Artery Atherosclerosis Esophageal Intestinal Metaplasia Dysplasia Bronchoscopic OCT/OFDI In Vivo Imaging Tool Pulmonary Airways Parenchyma Animal Models Human Airway OCT Imaging
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