Tolerability Testing
Tolerability Testing - Related Videos
14:09
Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
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Cited by 31 •
2013
We describe a "gold standard" for evaluating orthostatic tolerance (OT) using tilt testing with combined lower body negative pressure (LBNP). This can be combined with non-invasive evaluations of cardiovascular reflex control. Normal and abnormal responses are defined.
06:19
Testing Nicotine Tolerance in Aphids Using an Artificial Diet Experiment
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Cited by 5 •
2008
In this video and assay is demonstrated that tests the tolerance of nicotine to two types of aphids one that infests tobacco plants in the field and one that does not.
01:17
Salinity Tolerance of Alishewanella Species Isolated from Seawall Muddy Water
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2025
Begin with a culture of Alishewanella, a Gram-negative, salt-tolerant bacterium.Next, streak the culture onto agar plates containing increasing concentrations of sodium chloride to simulate varying levels of saline stress.Overlay each plate with a layer of unsolidified medium to prevent oxygen diffusion and maintain the culture in an oxygen-limited environment.Seal and incubate the plates at an optimum temperature to support bacterial growth.During incubation, the bacterium exhibits varying...
08:22
Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability
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Cited by 52 •
2017
This manuscript provides an updated remote supervision protocol that enables participation in transcranial direct current stimulation (tDCS) clinical trials while receiving treatment sessions from home. The protocol has been successfully piloted in both patients with multiple sclerosis and Parkinson's disease.
07:23
Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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Cited by 41 •
2014
We describe a protocol to examine the development of opioid-induced hyperalgesia and tolerance in mice. Based on the measurement of thermal and mechanical nociceptive responses of naïve and morphine-treated animals, it allows to quantify the increase in pain sensitivity (hyperalgesia) and decrease in analgesia (tolerance) associated with chronic opiate administration.
FAQs
A defined dose or exposure provides the reference point for interpreting unwanted effects. Controlled administration helps connect a reaction to the amount or conditions of treatment rather than to uncontrolled variation. Comparing observed symptoms with the exposure supports decisions about whether a reaction appears manageable, warrants dose adjustment, or should lead to treatment discontinuation.
These features describe different dimensions of an unwanted effect. Severity indicates how substantial the reaction is, timing shows when it occurs in relation to administration, and the treatment relationship addresses whether the intervention may have contributed. Considering them together helps distinguish expected, manageable reactions from effects that require changes in the treatment plan.
Results show how people or experimental models respond to a defined treatment exposure, including reactions that may limit continued administration. This information helps identify doses that can be studied while accounting for discomfort, adverse effects, and interruptions. The findings therefore connect observed responses with later decisions about dose selection and risk assessment.
Monitoring should capture signs and symptoms as they occur under controlled conditions, then document each unwanted effect by severity, timing, and apparent relationship to the intervention. Recording treatment interruptions is also important because it shows whether reactions interfere with continued administration. Together, these observations provide the evidence needed to interpret tolerability rather than relying on isolated complaints.
The assessment begins with administration of a defined dose or exposure to people or an experimental model under controlled conditions. Observers then monitor for signs, symptoms, and discomfort, recording the severity and timing of unwanted effects and their relationship to the intervention. Any treatment interruption is documented so the overall response can inform subsequent study decisions.
Medicine development uses these findings to support dose selection, study design, and risk assessment. If reactions remain expected and manageable, the intervention may be evaluated within an appropriately designed study. Effects that prompt dose adjustment or discontinuation provide information about limits on continued treatment and help determine whether development can progress.