Optic Neuritis
Optic Neuritis - Related Videos
12:23
Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
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Cited by 8 •
2014
Object From Motion (OFM) and Time-constrained stereo protocols are sensitive tools to identify monocular and binocular dynamic visual function deficits, which are uniquely affected in optic neuritis patients. Furthermore, these tests may be used as quantitative noninvasive tools to assess the extent of myelination along visual pathways.
08:05
Bioluminescence and Near-infrared Imaging of Optic Neuritis and Brain Inflammation in the EAE Model of Multiple Sclerosis in Mice
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Cited by 4 •
2017
We show a technique for in vivo live bioluminescence and near-infrared imaging of optic neuritis and encephalitis in the experimental autoimmune encephalomyelitis (EAE) model for multiple sclerosis in SJL/J mice.
04:18
Assessing Motor Function in an Experimental Autoimmune Neuritis Mouse Model
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2025
This video demonstrates the process of assessing motor dysfunction in a mouse model through the administration of Pertussis toxin and an inoculum containing myelin-mimicking peptides and adjuvants, followed by treadmill tests to assess motor function and evaluate the resulting nerve damage due to immune activation and demyelination.
08:31
Three-dimensional Optical-resolution Photoacoustic Microscopy
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Cited by 27 •
2011
Optical-resolution photoacoustic microscopy (OR-PAM) is an emerging technology capable of imaging optical absorption contrasts in vivo with cellular resolution and sensitivity. Here, we provide a visualized instruction on the experimental protocols of OR-PAM, including system configuration, system alignment, typical in vivo experimental procedures, and functional imaging schemes.
09:39
Optical Biosensing
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2023
Optical biosensors utilize light to detect the binding of a target molecule. These sensors can utilize a label molecule, which produces a measurable signal such as fluorescence, or these sensors can be label-free and use the changes in optical properties, such as refractive index, to sense for the binding of the target molecule. This video introduces both label and label-free optical biosensors, demonstrates their use in the laboratory, and shows some applications of the technology.
FAQs
Damage to the optic nerve’s myelin sheath interferes with the conduction of electrical signals from the eye toward the brain. Because visual information depends on efficient signal transmission along this pathway, demyelination can produce rapid vision loss and impaired color perception. This mechanism makes optic neuritis useful for examining how inflammation alters neural communication.
Pain that increases with eye movement reflects involvement of the inflamed optic nerve within the visual pathway. This symptom can accompany the visual changes caused by disrupted signal conduction and helps distinguish the clinical presentation from vision loss alone. Its presence also illustrates how inflammation can affect both neural function and sensory experience.
Several processes can contribute to optic neuritis, including an immune-mediated attack on myelin, infection, and other inflammatory disorders. The distinction matters because the underlying process may influence clinical interpretation, additional laboratory assessment, and treatment planning. Evaluating these possibilities prevents the condition from being understood only as a single form of demyelinating disease.
Optic neuritis provides a clinically relevant model for studying neuroinflammation and demyelination, the disruption of myelin around neural pathways. Its association with multiple sclerosis allows researchers to examine how immune-related injury affects signal conduction and visual function. Findings from this model can also support investigation of disease mechanisms, diagnosis, treatment, and prognosis.
Clinical evaluation may combine visual testing, magnetic resonance imaging, and laboratory assessment. Visual testing characterizes functional changes, while magnetic resonance imaging can examine relevant neural structures and laboratory studies help assess possible contributing inflammatory or infectious processes. Using these approaches together supports diagnosis and can provide information relevant to treatment decisions and prognosis.
Assessment findings help clinicians interpret the cause and extent of visual pathway involvement rather than relying on symptoms alone. Visual results, magnetic resonance imaging, and laboratory data can be considered together to support diagnosis, guide treatment, and estimate prognosis. In neuroscience, this combined approach connects measurable clinical outcomes with mechanisms of neuroinflammation and demyelination.