White Matter Undercut
White Matter Undercut - Related Videos
08:36
A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
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Cited by 21 •
2016
Here we present methodology for the production of a focal stroke in murine white matter by local injection of an irreversible endothelial nitric oxide synthase (eNOS) inhibitor (L-Nio). Presented are two stereotactic variations, retrograde neuronal tracing, and fresh tissue labeling and dissection that expand the potential applications of this technique.
07:58
Preparing Undercut Model of Posttraumatic Epileptogenesis in Rodents
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Cited by 14 •
2011
Partially isolated cortex (“undercut”) is an efficient animal model of posttraumatic epileptogenesis. Here we demonstrate how to make a novel surgical device and use it to make more precise and consistent lesions to generate this model.
05:15
Inducing White Matter Stroke in a Murine Model Using a Nitric Oxide Inhibitor
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2025
This video demonstrates the precise technique for inducing a white matter stroke in an anesthetized mouse by injecting a nitric oxide inhibitor at targeted brain coordinates within the white matter. This leads to blood vessel constriction and inhibition of blood supply, resulting in neuronal damage and a brain stroke.
10:05
DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions
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Cited by 13 •
2014
Diffusion tensor imaging (DTI) was performed to try to depict the major parts of the visual pathway. The goal was to use an FDA approved standard commercial workstation which could be used for everyday routine in order to try to reduce postoperative damage of the visual pathway in the patients.
02:49
Classifying Matter by State
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2020
Chemistry is the study of matter and the changes it undergoes. Matter is anything that has mass and occupies space. Matter is all around us; the air, water, soil, mountains, even our bodies are all examples of matter. Matter is divided into three states — solid, liquid, and gas — that are commonly found on earth. The fourth state of matter, plasma, occurs naturally in the interiors of stars. Solids are characterized by a definite shape and volume. In a solid, the particles (atoms or...
FAQs
The lesion interrupts axonal pathways beneath the selected cortical area, reducing signal exchange with structures such as the thalamus, brainstem, and other subcortical regions. Because these pathways normally connect cortical activity with deeper circuits, their disruption changes how local networks receive and transmit information. This makes the model useful for examining connectivity-dependent changes in cortical function.
Leaving much of the cortex intact allows researchers to study altered cortical function after its major connections have been disrupted, rather than examining damage to the cortical tissue alone. This separation helps distinguish effects associated with lost communication from effects associated with widespread cortical destruction. The resulting observations can clarify how remaining cortex responds to disconnection.
A White Matter Undercut permits analysis of how disrupted pathways influence local network activity, seizure propagation, and cortical reorganization. Interrupting communication with deeper structures can reveal whether activity changes remain localized or affect connected regions. These observations help link structural disconnection with altered neural dynamics and with the brain's capacity for functional adaptation.
Researchers can examine whether disconnecting cortical pathways changes the development of epileptogenesis, meaning processes associated with the emergence of seizure-related activity, and how seizures spread through neural networks. Comparing activity before and after the lesion provides a way to relate pathway disruption to changes in propagation. The model therefore connects anatomical disconnection with seizure behavior.
A typical study first records neural activity and behavior before the lesion to establish baseline measures. Researchers then surgically sever the white matter beneath a selected cortical region and assess activity and behavior afterward. Comparing the pre-lesion and post-lesion observations reveals changes associated with the disconnection while preserving a reference for interpreting functional effects.
Post-lesion studies can compare neural activity and behavior with their pre-lesion values. These measurements may show altered local network function, changes in seizure-related activity or spread, and behavioral effects associated with disrupted connectivity. The pattern of change helps researchers evaluate how the affected cortex functions after losing communication with deeper and other subcortical structures.
The model provides a controlled way to examine how cortical networks respond when communication pathways are disrupted, a condition relevant to traumatic or ischemic injury research. By following activity and behavior before and after the lesion, investigators can study cortical reorganization and functional recovery. These comparisons help characterize plasticity, the brain's capacity to adapt after connectivity changes.