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JoVE Journal Neuroscience
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Preparing Undercut Model of Posttraumatic Epileptogenesis in Rodents

Article DOI: 10.3791/2840 • 07:58 min • September 15th, 2011
September 15th, 2011 •
1, 1, 1, 1
1Department of Anatomy and Cell Biology, Department of Neurosurgery, Stark Neuroscience Research Institute, Indiana University School of Medicine

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Partially isolated cortex (“undercut”) is an efficient animal model of posttraumatic epileptogenesis. Here we demonstrate how to make a novel surgical device and use it to make more precise and consistent lesions to generate this model.

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Undercut Model Posttraumatic Epileptogenesis Rodents Surgical Procedure Sensorimotor Cortex White Matter Isolated Cortex Cerebral Cortex Brain Slices Epileptiform Discharges Electrical Seizures Behavior Seizures Animal Model Traumatic Brain Injury Precise Cortical Lesions Small Rodent Brain Surgery Technique Surgical Device Cutting Depth Cutting Angle Consistent Results Study On Mechanisms
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