A subscription to JoVE is required to view this content. Sign in or start your free trial.
9,278 Views
•
07:58 min
•
September 15, 2011
DOI:
Summary
Automatically generated
Partially isolated cortex (“undercut”) is an efficient animal model of posttraumatic epileptogenesis. Here we demonstrate how to make a novel surgical device and use it to make more precise and consistent lesions to generate this model.
Explore More Videos
Undercut ModelPosttraumatic EpileptogenesisRodentsSurgical ProcedureSensorimotor CortexWhite MatterIsolated CortexCerebral CortexBrain SlicesEpileptiform DischargesElectrical SeizuresBehavior SeizuresAnimal ModelTraumatic Brain InjuryPrecise Cortical LesionsSmall Rodent BrainSurgery TechniqueSurgical DeviceCutting DepthCutting AngleConsistent ResultsStudy On Mechanisms
Read Article
Cite this Article
Xiong, W., Ping, X., Gao, J., Jin, X. Preparing Undercut Model of Posttraumatic Epileptogenesis in Rodents. J. Vis. Exp. (55), e2840, doi:10.3791/2840 (2011).
Copy