A modified 3-D in vitro system is presented in which growth characteristics of several tumor cell lines in reconstituted basement membrane correlate with the dormant or proliferative behavior of the tumor cells at a metastatic secondary site in vivo.
Barkan, D., Green, J. E. An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth. J. Vis. Exp. (54), e2914, doi:10.3791/2914 (2011).