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July 22, 2014
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A highly sensitive ribozyme-based assay, applicable to high-throughput screening of chemicals targeting the unique process of RNA editing in trypanosomatid pathogens, is described in this paper. Inhibitors can be used as tools for hypothesis-driven analysis of the RNA editing process and ultimately as therapeutics.
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Moshiri, H., Mehta, V., Salavati, R. RNA Catalyst as a Reporter for Screening Drugs against RNA Editing in Trypanosomes. J. Vis. Exp. (89), e51712, doi:10.3791/51712 (2014).
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