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June 13, 2015
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We present an optimized inexpensive and reliable negative geotaxis assay in Drosophila melanogaster as a model for neurodegenerative disorders. Being more sensitive to mild locomotor defects, this assay will help screen for potential genetic interactions and drug targets.
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Madabattula, S. T., Strautman, J. C., Bysice, A. M., O’Sullivan, J. A., Androschuk, A., Rosenfelt, C., Doucet, K., Rouleau, G., Bolduc, F. Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders. J. Vis. Exp. (100), e52741, doi:10.3791/52741 (2015).
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