Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction

Guilielmus H.J.M. Ellenbroek; Gerardus P.J. van Hout; Leo Timmers; Pieter A. Doevendans; Gerard Pasterkamp; Imo E. Hoefer

doi:10.3791/54021

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Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction

JoVE Journal
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JoVE Journal Medycyna

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction

11,427 Views

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14:19 min

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October 14, 2016

DOI:

10.3791/54021-v

DOI:

10.3791/54021-v

•

14:19 min

October 14, 2016

•

7 Views

Guilielmus H.J.M. Ellenbroek¹, Gerardus P.J. van Hout^1,2, Leo Timmers^1,2, Pieter A. Doevendans^2,4, Gerard Pasterkamp^1,3, Imo E. Hoefer^1,3

¹Department of Experimental Cardiology,University Medical Center Utrecht, ²Department of Cardiology,University Medical Center Utrecht, ³Department of Clinical Chemistry and Hematology,University Medical Center Utrecht, ⁴Interuniversity Cardiology Institutes of the Netherlands (ICIN)

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Podsumowanie

Reliable and accurate outcome assessment is the key for translation of preclinical therapies into clinical treatment. The current paper describes how to assess three clinically relevant primary outcome parameters of cardiac performance and damage in a pig acute myocardial infarction model.