Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Bernhard N. Bohnert; Ferruh Artunc

doi:10.3791/57642

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Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

JoVE Journal
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JoVE Journal Medycyna

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

8,328 Views

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07:38 min

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May 06, 2018

DOI:

10.3791/57642-v

DOI:

10.3791/57642-v

•

07:38 min

May 06, 2018

•

4 Views

Bernhard N. Bohnert^1,2,3, Ferruh Artunc^1,2,3

¹Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry,University Hospital Tübingen, ²Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich,University Tübingen, ³German Center for Diabetes Research (DZD),University Tübingen

Transkrypcja

Podsumowanie

Here, we describe the induction of experimental nephrotic syndrome in 129S1/SvImJ mice by rapid retrobulbar injection of doxorubicin. We also treat nephrotic mice with sustained release pellets containing aprotinin to inhibit urinary serine protease activity and prevent sodium retention.