Flora Meilleur Department of Molecular and Structural Biochemistry North Carolina State University Biography Publications Institution JoVE Articles Flora Meilleur has not added a biography. If you are Flora Meilleur and would like to personalize this page please email our Author Liaison for assistance. Publications Joint X-ray/neutron Structure of Lentinus Similis AA9_A at Room Temperature Acta Crystallographica. Section F, Structural Biology Communications. Jan, 2023 | Pubmed ID: 36598350 Capture of Activated Dioxygen Intermediates at the Copper-active Site of a Lytic Polysaccharide Monooxygenase Chemical Science. Nov, 2022 | Pubmed ID: 36507176 Mapping H in the Nanoscale (AC)-Ag Fluorophore The Journal of Physical Chemistry Letters. Dec, 2022 | Pubmed ID: 36453924 Complementarity of Neutron, XFEL and Synchrotron Crystallography for Defining the Structures of Metalloenzymes at Room Temperature IUCrJ. Sep, 2022 | Pubmed ID: 36071813 Changes in Active-site Geometry on X-ray Photoreduction of a Lytic Polysaccharide Monooxygenase Active-site Copper and Saccharide Binding IUCrJ. Sep, 2022 | Pubmed ID: 36071795 The Mechanisms of Catalysis and Ligand Binding for the SARS-CoV-2 NSP3 Macrodomain from Neutron and X-ray Diffraction at Room Temperature Science Advances. May, 2022 | Pubmed ID: 35622909 The P132H Mutation in the Main Protease of Omicron SARS-CoV-2 Decreases Thermal Stability Without Compromising Catalysis or Small-molecule Drug Inhibition Cell Research. May, 2022 | Pubmed ID: 35292745 The Mechanisms of Catalysis and Ligand Binding for the SARS-CoV-2 NSP3 Macrodomain from Neutron and X-ray Diffraction at Room Temperature BioRxiv : the Preprint Server for Biology. Feb, 2022 | Pubmed ID: 35169801 Metalloprotein Catalysis: Structural and Mechanistic Insights into Oxidoreductases from Neutron Protein Crystallography Acta Crystallographica. Section D, Structural Biology. Oct, 2021 | Pubmed ID: 34605429 Preliminary Results of Neutron and X-ray Diffraction Data Collection on a Lytic Polysaccharide Monooxygenase Under Reduced and Acidic Conditions Acta Crystallographica. Section F, Structural Biology Communications. Apr, 2021 | Pubmed ID: 33830078 IMAGINE: The Neutron Protein Crystallography Beamline at the High Flux Isotope Reactor Methods in Enzymology. 2020 | Pubmed ID: 32093843 Dynamic Nuclear Polarization Enhanced Neutron Crystallography: Amplifying Hydrogen in Biological Crystals Methods in Enzymology. 2020 | Pubmed ID: 32093831 Neutron and X-ray Analysis of the Fenna-Matthews-Olson Photosynthetic Antenna Complex from Prosthecochloris Aestuarii Acta Crystallographica. Section F, Structural Biology Communications. Mar, 2019 | Pubmed ID: 30839291 Titration of Ionizable Groups in Proteins Using Multiple Neutron Data Sets from a Single Crystal: Application to the Small GTPase Ras Acta Crystallographica. Section F, Structural Biology Communications. Feb, 2019 | Pubmed ID: 30713162 IMAGINE: Neutrons Reveal Enzyme Chemistry Acta Crystallographica. Section D, Structural Biology. 08, 2018 | Pubmed ID: 30082513 Modulating Enzyme Activity by Altering Protein Dynamics with Solvent Biochemistry. 07, 2018 | Pubmed ID: 29901984 Structural Investigation of Cellobiose Dehydrogenase IIA: Insights from Small Angle Scattering into Intra- and Intermolecular Electron Transfer Mechanisms Biochimica Et Biophysica Acta. General Subjects. Apr, 2018 | Pubmed ID: 29374564 Neutron Crystallographic Studies of T4 Lysozyme at Cryogenic Temperature Protein Science : a Publication of the Protein Society. Oct, 2017 | Pubmed ID: 28707382 Neutron Structure of the T26H Mutant of T4 Phage Lysozyme Provides Insight into the Catalytic Activity of the Mutant Enzyme and How It Differs from That of Wild Type Protein Science : a Publication of the Protein Society. Oct, 2017 | Pubmed ID: 28707339 Structural Studies of Neurospora Crassa LPMO9D and Redox Partner CDHIIA Using Neutron Crystallography and Small-angle Scattering Carbohydrate Research. Aug, 2017 | Pubmed ID: 28291519 Crystallization of a Fungal Lytic Polysaccharide Monooxygenase Expressed from Glycoengineered Pichia Pastoris for X-ray and Neutron Diffraction Acta Crystallographica. Section F, Structural Biology Communications. 02, 2017 | Pubmed ID: 28177316 An Extended N-H Bond, Driven by a Conserved Second-order Interaction, Orients the Flavin N5 Orbital in Cholesterol Oxidase Scientific Reports. 01, 2017 | Pubmed ID: 28098177 Oxygen Activation at the Active Site of a Fungal Lytic Polysaccharide Monooxygenase Angewandte Chemie (International Ed. in English). 01, 2017 | Pubmed ID: 28004877 Crystal Structures of Wild-type Trichoderma Reesei Cel7A Catalytic Domain in Open and Closed States FEBS Letters. Dec, 2016 | Pubmed ID: 27943301 Neutron Protein Crystallography: A Complementary Tool for Locating Hydrogens in Proteins Archives of Biochemistry and Biophysics. Jul, 2016 | Pubmed ID: 26592456 Neutron Crystal Structure of RAS GTPase Puts in Question the Protonation State of the GTP γ-Phosphate The Journal of Biological Chemistry. Dec, 2015 | Pubmed ID: 26515069 Production and Characterization of Recombinant Perdeuterated Cholesterol Oxidase Analytical Biochemistry. Sep, 2015 | Pubmed ID: 26073659 Crystallization and Preliminary X-ray Diffraction Analysis of Hypocrea Jecorina Cel7A in Two New Crystal Forms Acta Crystallographica. Section F, Structural Biology Communications. Jun, 2014 | Pubmed ID: 24915091 Refinement of Macromolecular Structures Against Neutron Data with Journal of Applied Crystallography. Feb, 2014 | Pubmed ID: 24587788 New Insight into the Structure of RNA in Red Clover Necrotic Mosaic Virus and the Role of Divalent Cations Revealed by Small-angle Neutron Scattering Archives of Virology. Mar, 2013 | Pubmed ID: 23483344 Open Conformation of Ezrin Bound to Phosphatidylinositol 4,5-bisphosphate and to F-actin Revealed by Neutron Scattering The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22927432 Conformational Changes in Sindbis Virus Induced by Decreased PH Are Revealed by Small-angle Neutron Scattering Journal of Virology. Feb, 2012 | Pubmed ID: 22156534 Crystallization and Preliminary X-ray Diffraction Analysis of Red Clover Necrotic Mosaic Virus Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Nov, 2010 | Pubmed ID: 21045294 The Structure of Sindbis Virus Produced from Vertebrate and Invertebrate Hosts As Determined by Small-angle Neutron Scattering Journal of Virology. May, 2010 | Pubmed ID: 20219936 Deuterium Labeling for Neutron Structure-function-dynamics Analysis Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19488706 Expression, Purification, Assay, and Crystal Structure of Perdeuterated Human Arginase I Archives of Biochemistry and Biophysics. Sep, 2007 | Pubmed ID: 17562323 Neutron Scattering in the Biological Sciences: Techniques And Applications Flora Meilleur1,2 1Department of Molecular and Structural Biochemistry, North Carolina State University, 2Neutron Scattering Division, Oak Ridge National Laboratory JoVE 64806 Editorial Neutron Crystallography Data Collection and Processing for Modelling Hydrogen Atoms in Protein Structures Gabriela C. Schröder1,2, Flora Meilleur1,2 1Department of Molecular and Structural Biochemistry, North Carolina State University, 2Neutron Scattering Division, Oak Ridge National Laboratory JoVE 61903 Química
Neutron Scattering in the Biological Sciences: Techniques And Applications Flora Meilleur1,2 1Department of Molecular and Structural Biochemistry, North Carolina State University, 2Neutron Scattering Division, Oak Ridge National Laboratory JoVE 64806 Editorial
Neutron Crystallography Data Collection and Processing for Modelling Hydrogen Atoms in Protein Structures Gabriela C. Schröder1,2, Flora Meilleur1,2 1Department of Molecular and Structural Biochemistry, North Carolina State University, 2Neutron Scattering Division, Oak Ridge National Laboratory JoVE 61903 Química
