Roger Lecomte Department of Nuclear Medicine and Radiobiology Université de Sherbrooke Biography Publications Institution JoVE Articles Roger Lecomte has not added a biography. If you are Roger Lecomte and would like to personalize this page please email our Author Liaison for assistance. Publications Improved Estrogen Receptor Assessment by PET Using the Novel RadiotracerF-4FMFES in Estrogen Receptor-Positive Breast Cancer Patients: An Ongoing Phase II Clinical Trial Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Feb, 2018 | Pubmed ID: 28798032 Targeting IL-5Rα with Antibody-conjugates Reveals a Strategy for Imaging and Therapy for Invasive Bladder Cancer Oncoimmunology. 2017 | Pubmed ID: 29123949 The Loss of P2X7 Receptor Expression Leads to Increase Intestinal Glucose Transit and Hepatic Steatosis Scientific Reports. Oct, 2017 | Pubmed ID: 29018292 Loss of UCP2 Impairs Cold-induced Non-shivering Thermogenesis by Promoting a Shift Toward Glucose Utilization in Brown Adipose Tissue Biochimie. Mar, 2017 | Pubmed ID: 28130074 Impact of Dianionic and Dicationic Linkers on Tumor Uptake and Biodistribution of [(64) Cu]Cu/NOTA Peptide-based Gastrin-releasing Peptide Receptors Antagonists Journal of Labelled Compounds & Radiopharmaceuticals. Apr, 2017 | Pubmed ID: 28129446 A Novel Positron Emission Tomography (PET) Approach to Monitor Cardiac Metabolic Pathway Remodeling in Response to Sunitinib Malate PloS One. 2017 | Pubmed ID: 28129334 Simulation of Scintillation Light Output in LYSO Scintillators Through a Full Factorial Design Physics in Medicine and Biology. Jan, 2017 | Pubmed ID: 28050968 Clinical Trial with Sodium (99m)Tc-Pertechnetate Produced by a Medium-Energy Cyclotron: Biodistribution and Safety Assessment in Patients with Abnormal Thyroid Function Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. May, 2017 | Pubmed ID: 27738005 MTORC1 is Required for Brown Adipose Tissue Recruitment and Metabolic Adaptation to Cold Scientific Reports. Nov, 2016 | Pubmed ID: 27876792 Real-Time Microfluidic Blood-Counting System for PET and SPECT Preclinical Pharmacokinetic Studies Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Sep, 2016 | Pubmed ID: 27151983 Postprandial Fatty Acid Uptake and Adipocyte Remodeling in Angiotensin Type 2 Receptor-deficient Mice Fed a High-fat/high-fructose Diet Adipocyte. Jan-Mar, 2016 | Pubmed ID: 27144096 Metabolic Activity of Brown, "beige," and White Adipose Tissues in Response to Chronic Adrenergic Stimulation in Male Mice American Journal of Physiology. Endocrinology and Metabolism. Jul, 2016 | Pubmed ID: 27143559 Transcriptional Changes Associated with Long-Term Left Ventricle Volume Overload in Rats: Impact on Enzymes Related to Myocardial Energy Metabolism BioMed Research International. 2015 | Pubmed ID: 26583150 Multipinhole SPECT Helical Scan Parameters and Imaging Volume Medical Physics. Nov, 2015 | Pubmed ID: 26520751 Radioisotopic Purity of Sodium Pertechnetate 99mTc Produced with a Medium-Energy Cyclotron: Implications for Internal Radiation Dose, Image Quality, and Release Specifications Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Oct, 2015 | Pubmed ID: 26205300 A Real-time Follow-up of Photodynamic Therapy During PET Imaging Photodiagnosis and Photodynamic Therapy. Sep, 2015 | Pubmed ID: 26007241 [(18)F]-fluorodeoxyglucose Positron Emission Tomography of the Cat Brain: A Feasibility Study to Investigate Osteoarthritis-associated Pain Veterinary Journal (London, England : 1997). Jun, 2015 | Pubmed ID: 25951988 In Vivo Measurement of Energy Substrate Contribution to Cold-induced Brown Adipose Tissue Thermogenesis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2015 | Pubmed ID: 25681456 Optimization of the Reference Region Method for Dual Pharmacokinetic Modeling Using Gd-DTPA/MRI and (18) F-FDG/PET Magnetic Resonance in Medicine. Feb, 2015 | Pubmed ID: 24604379 Endurance Training or Beta-blockade Can Partially Block the Energy Metabolism Remodeling Taking Place in Experimental Chronic Left Ventricle Volume Overload BMC Cardiovascular Disorders. Dec, 2014 | Pubmed ID: 25518920 A Longitudinal Low Dose μCT Analysis of Bone Healing in Mice: A Pilot Study Advances in Orthopedics. 2014 | Pubmed ID: 25431676 [(11)C]-Acetoacetate PET Imaging: a Potential Early Marker for Cardiac Heart Failure Nuclear Medicine and Biology. Nov-Dec, 2014 | Pubmed ID: 25195015 Deciphering PDT-induced Inflammatory Responses Using Real-time FDG-PET in a Mouse Tumour Model Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology. Oct, 2014 | Pubmed ID: 25058054 Arterial Input Function Sampling Without Surgery in Rats for Positron Emission Tomography Molecular Imaging Nuclear Medicine Communications. Jun, 2014 | Pubmed ID: 24594981 Imaging Performance of LabPET APD-based Digital PET Scanners for Pre-clinical Research Physics in Medicine and Biology. Feb, 2014 | Pubmed ID: 24442278 Comment on "Temperature Dependence of APD-based PET Scanners" [Med. Phys. 40(9) 092506 (13pp.) (2013)] Medical Physics. Jan, 2014 | Pubmed ID: 24387535 Fully 3D Iterative CT Reconstruction Using Polar Coordinates Medical Physics. Nov, 2013 | Pubmed ID: 24320437 (68)Ga/DOTA- and (64)Cu/NOTA-phthalocyanine Conjugates As Fluorescent/PET Bimodal Imaging Probes Bioconjugate Chemistry. Sep, 2013 | Pubmed ID: 23978056 Angiotensin II-converting Enzyme Inhibition Improves Survival, Ventricular Remodeling, and Myocardial Energetics in Experimental Aortic Regurgitation Circulation. Heart Failure. Sep, 2013 | Pubmed ID: 23861486 Assessment of the Novel Estrogen Receptor PET Tracer 4-fluoro-11β-methoxy-16α-[(18)F]fluoroestradiol (4FMFES) by PET Imaging in a Breast Cancer Murine Model Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging. Oct, 2013 | Pubmed ID: 23619898 Mammary Cancer Bone Metastasis Follow-up Using Multimodal Small-animal MR and PET Imaging Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Jun, 2013 | Pubmed ID: 23596003 PET-based Geometrical Calibration of a Pinhole SPECT Add-on for an Animal PET Scanner Physics in Medicine and Biology. Apr, 2013 | Pubmed ID: 23458923 Conversion of Arterial Input Functions for Dual Pharmacokinetic Modeling Using Gd-DTPA/MRI and 18F-FDG/PET Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Mar, 2013 | Pubmed ID: 22570280 Toward Truly Combined PET/CT Imaging Using PET Detectors and Photon Counting CT with Iterative Reconstruction Implementing Physical Detector Response Medical Physics. Sep, 2012 | Pubmed ID: 28524989 Quantitative Hormone Therapy Follow-up in an ER+/ERαKD Mouse Tumor Model Using FDG and [11C]-methionine PET Imaging EJNMMI Research. 2012 | Pubmed ID: 23140372 The Ketogenic Diet Increases Brain Glucose and Ketone Uptake in Aged Rats: a Dual Tracer PET and Volumetric MRI Study Brain Research. Dec, 2012 | Pubmed ID: 23063891 Blood Compatible Microfluidic System for Pharmacokinetic Studies in Small Animals Lab on a Chip. Nov, 2012 | Pubmed ID: 23000896 Toward Truly Combined PET/CT Imaging Using PET Detectors and Photon Counting CT with Iterative Reconstruction Implementing Physical Detector Response Medical Physics. Sep, 2012 | Pubmed ID: 22957635 EP 80317, a Selective CD36 Ligand, Shows Cardioprotective Effects Against Post-ischaemic Myocardial Damage in Mice Cardiovascular Research. Oct, 2012 | Pubmed ID: 22787133 Novel Radiolabeled Peptides for Breast and Prostate Tumor PET Imaging: (64)Cu/and (68)Ga/NOTA-PEG-[D-Tyr(6),βAla(11),Thi(13),Nle(14)]BBN(6-14) Bioconjugate Chemistry. Aug, 2012 | Pubmed ID: 22770480 NEMA NU 4-2008 Comparison of Preclinical PET Imaging Systems Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Aug, 2012 | Pubmed ID: 22699999 Small-animal PET: What is It, and Why Do We Need It? Journal of Nuclear Medicine Technology. Sep, 2012 | Pubmed ID: 22582006 Positron Emission Tomography Detection of Human Endothelial Cell and Fibroblast Monolayers: Effect of Pretreament and Cell Density on 18FDG Uptake Vascular Cell. 2012 | Pubmed ID: 22433292 Comparative Study of 64Cu/NOTA-[D-Tyr6,βAla11,Thi13,Nle14]BBN(6-14) Monomer and Dimers for Prostate Cancer PET Imaging EJNMMI Research. 2012 | Pubmed ID: 22333272 Predicting Efficacy of Photodynamic Therapy by Real-time FDG-PET in a Mouse Tumour Model Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology. Feb, 2012 | Pubmed ID: 22234417 [11C]Acetate Rest-stress Protocol to Assess Myocardial Perfusion and Oxygen Consumption Reserve in a Model of Congestive Heart Failure in Rats Nuclear Medicine and Biology. Feb, 2012 | Pubmed ID: 22079038 [18F]-fluoroestradiol Quantitative PET Imaging to Differentiate ER+ and ERα-knockdown Breast Tumors in Mice Nuclear Medicine and Biology. Jan, 2012 | Pubmed ID: 22079037 PET Imaging Using 64Cu-labeled Sulfophthalocyanines: Synthesis and Biodistribution Bioorganic & Medicinal Chemistry Letters. Dec, 2011 | Pubmed ID: 22050887 Mild Experimental Ketosis Increases Brain Uptake of 11C-acetoacetate and 18F-fluorodeoxyglucose: a Dual-tracer PET Imaging Study in Rats Nutritional Neuroscience. Mar, 2011 | Pubmed ID: 21605500 Mono- and Tri-cationic Porphyrin-monoclonal Antibody Conjugates: Photodynamic Activity and Mechanism of Action Immunology. Feb, 2011 | Pubmed ID: 21039468 Behavioral, Medical Imaging and Histopathological Features of a New Rat Model of Bone Cancer Pain PloS One. 2010 | Pubmed ID: 21048940 Image-derived Input Function in Dynamic Human PET/CT: Methodology and Validation with 11C-acetate and 18F-fluorothioheptadecanoic Acid in Muscle and 18F-fluorodeoxyglucose in Brain European Journal of Nuclear Medicine and Molecular Imaging. Aug, 2010 | Pubmed ID: 20437239 Cyclotron Production of 99mTc: an Approach to the Medical Isotope Crisis Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Apr, 2010 | Pubmed ID: 20351346 Abnormal in Vivo Myocardial Energy Substrate Uptake in Diet-induced Type 2 Diabetic Cardiomyopathy in Rats American Journal of Physiology. Endocrinology and Metabolism. May, 2010 | Pubmed ID: 20159856 A Pulse Simulator for Crystal Identification Validation of Phoswich Detectors Used in Positron Emission Tomography Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. 2009 | Pubmed ID: 19964462 PET Study of 11C-acetoacetate Kinetics in Rat Brain During Dietary Treatments Affecting Ketosis American Journal of Physiology. Endocrinology and Metabolism. Apr, 2009 | Pubmed ID: 19176356 Novel Detector Technology for Clinical PET European Journal of Nuclear Medicine and Molecular Imaging. Mar, 2009 | Pubmed ID: 19107476 Mechanism of Reduced Myocardial Glucose Utilization During Acute Hypertriglyceridemia in Rats Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging. Jan-Feb, 2009 | Pubmed ID: 18769973 [11C] Acetoacetate Utilization by Breast and Prostate Tumors: a PET and Biodistribution Study in Mice Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging. Jul-Aug, 2008 | Pubmed ID: 18454299 Comparison of Analytical and Algebraic 2D Tomographic Reconstruction Approaches for Irregularly Sampled MicroCT Data Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. 2007 | Pubmed ID: 18002605 Standardization and Detailed Characterization of the Syngeneic Fischer/F98 Glioma Model The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. Aug, 2007 | Pubmed ID: 17803026 A New Tool for Molecular Imaging: the Microvolumetric Beta Blood Counter Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Jul, 2007 | Pubmed ID: 17574990 A Small Animal Positron Emission Tomography Study of the Effect of Chemotherapy and Hormonal Therapy on the Uptake of 2-deoxy-2-[F-18]fluoro-D-glucose in Murine Models of Breast Cancer Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging. May-Jun, 2007 | Pubmed ID: 17334852 PET Imaging of Apoptosis with (64)Cu-labeled Streptavidin Following Pretargeting of Phosphatidylserine with Biotinylated Annexin-V European Journal of Nuclear Medicine and Molecular Imaging. Feb, 2007 | Pubmed ID: 17021816 Dynamic Imaging of Transient Metabolic Processes by Small-animal PET for the Evaluation of Photosensitizers in Photodynamic Therapy of Cancer Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Jul, 2006 | Pubmed ID: 16818946 The Effect of Insulin on the Intracellular Distribution of 14(R,S)-[18F]Fluoro-6-thia-heptadecanoic Acid in Rats Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging. Jul-Aug, 2006 | Pubmed ID: 16791750 Positron Emission Tomography Imaging of Tumor Response After Photodynamic Therapy Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer. 2006 | Pubmed ID: 16566721 Endotoxin-induced Heart Dysfunction in Rats: Assessment of Myocardial Perfusion and Permeability and the Role of Fluid Resuscitation Critical Care Medicine. Jan, 2006 | Pubmed ID: 16374166 Quantitative Myocardial Perfusion and Coronary Reserve in Rats with 13N-ammonia and Small Animal PET: Impact of Anesthesia and Pharmacologic Stress Agents Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Nov, 2004 | Pubmed ID: 15534064 Breast Cancer Models to Study the Expression of Estrogen Receptors with Small Animal PET Imaging Nuclear Medicine and Biology. Aug, 2004 | Pubmed ID: 15246367 Respiratory Gating for 3-dimensional PET of the Thorax: Feasibility and Initial Results Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Feb, 2004 | Pubmed ID: 14960638 Quantitative Gated PET for the Assessment of Left Ventricular Function in Small Animals Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Oct, 2003 | Pubmed ID: 14530482 Assessment of Cancer-associated Biomarkers by Positron Emission Tomography: Advances and Challenges Disease Markers. 2002 | Pubmed ID: 14646039 Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting Simon Beaudoin1, Michel Paquette1, Laurent Fafard-Couture1, Mylene A. Tremblay1, Roger Lecomte1,2,3, Brigitte Guérin1,2,3, Jeffrey V. Leyton1,2,3 1Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke, 2Sherbrooke Molecular Imaging Center (CIMS), Université de Sherbrooke, 3Sherbrooke Institute of Pharmacology JoVE 55440 Bioengenharia A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat Maggie Roy1, Scott Nugent1, Sébastien Tremblay2, Maxime Descoteaux3, Jean-François Beaudoin2, Luc Tremblay2, Roger Lecomte2,4, Stephen C Cunnane1 1Research Center on Aging and Department of Physiology and Biophysics, Université de Sherbrooke, 2Sherbrooke Molecular Imaging Center, Étienne-Le Bel Clinical Research Center, Université de Sherbrooke, 3Department of Computer Science, Université de Sherbrooke, 4Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke JoVE 50761 Neurociência
Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting Simon Beaudoin1, Michel Paquette1, Laurent Fafard-Couture1, Mylene A. Tremblay1, Roger Lecomte1,2,3, Brigitte Guérin1,2,3, Jeffrey V. Leyton1,2,3 1Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke, 2Sherbrooke Molecular Imaging Center (CIMS), Université de Sherbrooke, 3Sherbrooke Institute of Pharmacology JoVE 55440 Bioengenharia
A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat Maggie Roy1, Scott Nugent1, Sébastien Tremblay2, Maxime Descoteaux3, Jean-François Beaudoin2, Luc Tremblay2, Roger Lecomte2,4, Stephen C Cunnane1 1Research Center on Aging and Department of Physiology and Biophysics, Université de Sherbrooke, 2Sherbrooke Molecular Imaging Center, Étienne-Le Bel Clinical Research Center, Université de Sherbrooke, 3Department of Computer Science, Université de Sherbrooke, 4Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke JoVE 50761 Neurociência
