Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Kirsten S. Evonuk; Carson E. Moseley; Ryan E. Doyle; Casey T. Weaver; Tara M. DeSilva

doi:10.3791/54348

Journal

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Imunologia e Infecção

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Determinar a supressão imune Sistema contra CNS Proteção para farmacológicos intervenções na desmielinização auto-imune

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

JoVE Journal
Imunologia e Infecção

This content is Free Access.

JoVE Journal Imunologia e Infecção

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Determinar a supressão imune Sistema contra CNS Proteção para farmacológicos intervenções na desmielinização auto-imune

Please note that all translations are automatically generated. Click here for the English version.

12,067 Views

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09:38 min

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September 12, 2016

DOI:

10.3791/54348-v

DOI:

10.3791/54348-v

•

09:38 min

September 12, 2016

•

4 Views

Kirsten S. Evonuk*¹, Carson E. Moseley*², Ryan E. Doyle¹, Casey T. Weaver², Tara M. DeSilva^1,3,4

¹Physical Medicine and Rehabilitation,University of Alabama at Birmingham, ²Department of Pathology,University of Alabama at Birmingham, ³Department of Neurobiology,University of Alabama at Birmingham, ⁴Center for Glial Biology and Medicine,University of Alabama at Birmingham

Transcrição

Summary

This protocol describes how to determine whether pharmacological treatments for experimental autoimmune encephalomyelitis show CNS protection as a consequence of suppressing immune cell infiltration or are neuroprotective during the onslaught of immune cell infiltration.