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A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
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A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Article DOI: 10.3791/61158-v • 05:14 min • May 16th, 2020
May 16th, 2020 •
1, 1, 1, 1, 1, 1
1Department of Cardiology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University

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Described is a protocol to establish a Doxorubicin-induced dilated cardiomyopathy (DCM) model in mice via long-term intraperitoneal injection of Doxorubicin.

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Doxorubicin-induced Murine Model Dilated Cardiomyopathy In Vivo Stable Reliable Economical Pathogenesis New Drugs Dissolve Doxorubicin Hydrochloride Sterilized Water Concentration Vortex Store Four Degrees Celsius 8-10 Week-old Mice Pathogen-free Mouse Cages 12-hour Light-dark Cycle Constant Temperature Food And Water Control Group Dox Group Sterilized Syringes Intraperitoneal Injection Five Milligrams Per Kilogram Of Body Weight Lower Left Or Right Quadrant Of Abdomen Urinary Bladder Abdominal Organs Body Weight Measurement Injection Dose Adjustment Anesthesia Confirmation Depilatory Cream Removal Echocardiography M-mode Tracings
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