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Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Article DOI: 10.3791/64329-v • 08:25 min • September 26th, 2022
September 26th, 2022 •
1, 2, 1, 3
1Department of Clinical Immunology, Wroclaw Medical University, 2Department of Medical Physiology, Chair of Biomedical Sciences, Institute of Physiotherapy, Faculty of Health Sciences, Jagiellonian University Medical College, 3Chair of Biomedical Sciences, Faculty of Health Sciences, Jagiellonian University Medical College

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Contact hypersensitivity (CHS) is a murine experimental model of allergic contact dermatitis (ACD). CHS is based on sensitization with reactive hapten by painting the shaved skin of the chest and abdomen, with a subsequent ear skin challenge with a diluted hapten, causing a swelling reaction that is assessed in various ways.

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Contact Hypersensitivity Allergic Contact Dermatitis Murine Model Laboratory Method Ear Edema Cellular Mechanisms T-cell Dependent Immune Responses New Therapies Shaving Mouse Skin Labeling The Paw Sensitizing Mice Hapten Application Ear Thickness Measurement
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