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JoVE Journal Bioengineering
A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue
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A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue

Article DOI: 10.3791/64334-v • 13:45 min • November 11th, 2022
November 11th, 2022 •
1, 1, 1,2, 1,3, 4, 1,3, 1,2, 1,3
1Department of Biomedical Engineering, Erasmus Medical Center, 2Department of Biomedical Engineering, Eindhoven University of Technology, 3Department of Biomechanical Engineering, Delft University of Technology, 4Erasmus Optical Imaging Center, Erasmus Medical Center

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We have developed a mechano-imaging pipeline to study the heterogeneous structural and mechanical atherosclerotic plaque properties. This pipeline enables correlation of the local predominant angle and dispersion of collagen fiber orientation, the rupture behavior, and the strain fingerprints of the fibrous plaque tissue.

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Correlation Collagen Structure Mechanical Properties Atherosclerotic Plaque Fibrous Tissue Protocol Local Assessments Structural Assessments Mechanical Assessments Functional Link Tissue Sample Fibrous Plaque Tissue Structure Failure Characteristics Clinical Fatal Events Plaque Rupture Longitudinal Axis Surgical Scissors Tweezers Rectangular Test Samples Silicone Pinning Needles Tensile Testing Device Safety Glasses Side Cutter Petri Dish PBS Microscope System
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