Name: Abordagem cirúrgica para a obtenção completa de allogenxerto facial de tecidos moles para alotransplante compósitos vascularizados (Vídeo) | JoVE Journal
Uploaded: 2025-12-30T14:33:00.000+00:00
Duration: 9 min 14 s
Description: Aprenda a técnica cirúrgica padronizada para obtenção completa de aloenxerto facial de tecidos moles, preservando estruturas vasculares e neurais. Este protocolo detalhado otimiza a segurança e reprodutibilidade em transplantes faciais compostos vascularizados.

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<li>Smeets, R., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Face+transplantation%3A+On+the+verge+of+becoming+clinical+routine%5BTitle%5D)+AND+%22Biomed+Res+Int%22%5BJournal%5D)">Face transplantation: On the verge of becoming clinical routine.</a> Biomed Res Int. 2014, 907272(2014).</li>
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<li>Sosin, M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Total+face%2C+eyelids%2C+ears%2C+scalp%2C+and+skeletal+subunit+transplant%3A+A+reconstructive+solution+for+the+full+face+and+total+scalp+burn%5BTitle%5D)+AND+%22Plast+Reconstr+Surg%22%5BJournal%5D)">Total face, eyelids, ears, scalp, and skeletal subunit transplant: A reconstructive solution for the full face and total scalp burn.</a> Plast Reconstr Surg. 138 (1), 205-219 (2016).</li>
<li>Perraudin, T., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Vascularized+composite+upper+limb+allograft+harvesting+for+proximal+arm+allotransplantation%5BTitle%5D)+AND+%22J+Vis+Exp%22%5BJournal%5D)">Vascularized composite upper limb allograft harvesting for proximal arm allotransplantation.</a> J Vis Exp. (220), e68170(2025).</li>
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<li>Gurunian, R., Rampazzo, A., Papay, F., Gharb, B. b <a target="_blank" href="http://scholar.google.com/scholar?hl=en&safe=off&q=author%3aGurunian%2C+R+%22Reconstructive+transplantation%22">Reconstructive transplantation</a>. , Springer. Nature, Switzerland. (2023).</li>
<li>Pomahac, B., Gobble, R. M., Schneeberger, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Facial+and+hand+allotransplantation%5BTitle%5D)+AND+%22Cold+Spring+Harb+Perspect+Med%22%5BJournal%5D)">Facial and hand allotransplantation.</a> Cold Spring Harb Perspect Med. 4 (3), a015651(2014).</li>
<li>Lupon, E., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((A+new+method+for+preparation+of+decellularized+human+scaffolds+for+facial+reconstruction%5BTitle%5D)+AND+%22Curr+Issues+Mol+Biol%22%5BJournal%5D)">A new method for preparation of decellularized human scaffolds for facial reconstruction.</a> Curr Issues Mol Biol. 47 (4), 275(2025).</li>
<li>Julienne, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((flap+harvest+training+on+a+new+ultrarealistic+simulation+model%3A+In-training+operator+feedback+about+a+pulsating+reperfused+and+reventilated+cadaver+simlife%C2%AE%5BTitle%5D)+AND+%22Ann+Chir+Plast+Esthet%22%5BJournal%5D)">flap harvest training on a new ultrarealistic simulation model: In-training operator feedback about a pulsating reperfused and reventilated cadaver simlife®.</a> Ann Chir Plast Esthet. 66 (2), 126-133 (2021).</li>
<li>Rodríguez-Lorenzo, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Vascular+perfusion+of+the+facial+skin%3A+Implications+in+allotransplantation+of+facial+aesthetic+subunits%5BTitle%5D)+AND+%22Plast+Reconstr+Surg%22%5BJournal%5D)">Vascular perfusion of the facial skin: Implications in allotransplantation of facial aesthetic subunits.</a> Plast Reconstr Surg. 138 (5), 1073-1079 (2016).</li>
<li>Quilichini, J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Restoration+of+the+donor+after+face+graft+procurement+for+allotransplantation%3A+Report+on+the+technique+and+outcomes+of+seven+cases%5BTitle%5D)+AND+%22Plast+Reconstr+Surg%22%5BJournal%5D)">Restoration of the donor after face graft procurement for allotransplantation: Report on the technique and outcomes of seven cases.</a> Plast Reconstr Surg. 129 (5), 1105-1111 (2012).</li>
<li>Baker, C. E., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Pretreatments+of+ex+vivo+vascularized+composite+allografts%3A+A+scoping+review%5BTitle%5D)+AND+%22Ann+Plast+Surg%22%5BJournal%5D)">Pretreatments of ex vivo vascularized composite allografts: A scoping review.</a> Ann Plast Surg. , (2025).</li>
<li>Njessi, P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Preservation+strategies+for+vascularized+composite+allotransplantation%3A+An+updated+systematic+review+of+a+rapidly+expanding+field%5BTitle%5D)+AND+%22bioRxiv%22%5BJournal%5D)">Preservation strategies for vascularized composite allotransplantation: An updated systematic review of a rapidly expanding field.</a> bioRxiv. , (2025).</li>
<li>Lupon, E., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((An+experimental+human+diep+flap+model+to+investigate+preservation+strategies+for+vascularized+composite+allografts+and+free+flaps%5BTitle%5D)+AND+%22J+Vis+Exp%22%5BJournal%5D)">An experimental human diep flap model to investigate preservation strategies for vascularized composite allografts and free flaps.</a> J Vis Exp. (226), e69392(2025).</li>
<li>Lupon, E., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Engineering+vascularized+composite+allografts+using+natural+scaffolds%3A+A+systematic+review%5BTitle%5D)+AND+%22Tissue+Eng+Part+B+Rev%22%5BJournal%5D)">Engineering vascularized composite allografts using natural scaffolds: A systematic review.</a> Tissue Eng Part B Rev. , (2021).</li>
</ol>

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abordagem cirúrgica para a obtenção completa de allogenxerto facial de tecidos moles para alotransplante compósitos vascularizados

Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation

Abordagem cirúrgica para a obtenção completa de allogenxerto facial de tecidos moles para alotransplante compósitos vascularizados

Full facial vascularized composite allotransplantation (VCA) offers a reconstructive option for patients with severe facial disfigurement who cannot be ...

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Vascularizado Composite Allotransplantations (VCA) tornaram-se uma realidade clínica. No entanto, a vasta aplicação clínica de VCA é limitada pela imunossupressão multi-droga crónica. Os autores apresentam um grande modelo animal confiável e reprodutível para traduzir estratégias inovadoras imunomoduladores que podem minimizar ou potencialmente eliminar a necessidade de imunossupressão em VCA.

Um modelo de transplante heterotópico Modificado Swine Hind Limb para Translational vascularizado Composite Alotransplante (VCA) Pesquisa

O allograft composto vascularized oferece benefícios Life-alterando aos receptores da transplantação, mas as causas biológicas da rejeição da corrupção e do vasculopatia permanecem mal compreendidas. O modelo cirúrgico do roedor apresentado aqui apresenta um modelo de transplante reprodutível e clinicamente relevante, permitindo que os pesquisadores avaliem eventos de rejeição e potenciais estratégias terapêuticas para prevenir sua ocorrência.

Modelo Osteomyocutaneous Heterotopic modificado da aleta do Hindmembro no rato para a pesquisa de Allotransplante composta Vascularized translacional

O presente protocolo descreve o modelo de retalho fascio-cutâneo suíno e seu potencial uso na pesquisa de tecidos compostos vascularizados.

Um modelo confiável de retalho fasciocutâneo suíno para estudos de bioengenharia de aloenxertos compostos vascularizados

O protocolo descreve a captação cirúrgica e subsequente descelularização de retalhos suínos vascularizados pela perfusão de detergente dodecil sulfato de sódio através da vasculatura do retalho em um biorreator de perfusão personalizado.

Aquisição e Perfusão-Descelularização de Flaps Vascularizados Suínos em Biorreator de Perfusão Customizado

Descrevemos a técnica cirúrgica e o processo de descelularização de membros posteriores compostos de ratos. A descelularização é realizada usando dodecil sulfato de sódio de baixa concentração através de um sistema de perfusão de máquina ex vivo.

Captação e Descelularização de Membros Posteriores de Rato Usando Biorreator Ex Vivo à Base de Perfusão para Alotransplante Composto Vascularizado

Aqui, apresentamos um protocolo para aquisição e preparação de aloenxertos de mão compostos vascularizados durante o transplante distal ou proximal do antebraço.

Aquisição e preparação de aloenxerto composto vascularizado da mão para alotransplante distal e proximal do antebraço: uma abordagem passo a passo

Aqui, o protocolo explica passo a passo a técnica de coleta de um aloenxerto de braço no nível transumeral ou glenoumeral durante um alotransplante de braço.

Colheita de aloenxerto de membro superior composto vascularizado para alotransplante de braço proximal

Este protocolo descreve um procedimento passo a passo para a coleta de um aloenxerto de parede abdominal vascularizado e reinervado, detalhando seus marcos anatômicos, requisitos técnicos e futuras aplicações clínicas potenciais.

Obtenção de um alotransplante de parede abdominal vascularizada e reinervada

Este protocolo descreve a técnica cirúrgica para a coleta de um modelo de retalho perfurante humano baseado no pedículo profundo da artéria epigástrica inferior, destinado a pesquisa experimental.

Um modelo experimental de retalho DIEP humano para investigar estratégias de preservação para alenxertos compostos vascularizados e retalhos livres

Apresentamos um modelo reprodutível de camundongo de alotransplante composto vascularizado de membros posteriores para pescoço, heterotópico. Esse protocolo supermicrocirúrgico, envolvendo anastomoses de vasos de 0,3 a 0,5 mm, integra guiagem com filamento de náilon e algemamento venoso. Ela oferece uma plataforma confiável para estudos translacionais sobre tolerância, lesões por isquemia-reperfusão e mecanismos imunológicos em alotransplante composto vascularizado.

Transplante Heterotópico de Membro Posterior para Pescoço no Camundongo: Um Modelo Supermicrocirúrgico de Alotransplante Composto Vascularizado

Aprenda a técnica cirúrgica padronizada para obtenção completa de aloenxerto facial de tecidos moles, preservando estruturas vasculares e neurais. Este protocolo detalhado otimiza a segurança e reprodutibilidade em transplantes faciais compostos vascularizados.

Abordagem cirúrgica para a obtenção completa de allogenxerto facial de tecidos moles para alotransplante compósitos vascularizados (Vídeo) | JoVE Journal

Abordagem cirúrgica para a obtenção completa de allogenxerto facial de tecidos moles para alotransplante compósitos vascularizados

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