Туберкулез легких II: Патофизиология

When susceptible hosts inhale aerosolized droplets containing Mycobacterium tuberculosis, the bacteria reach the lungs' alveoli where alveolar macrophages engulf them. However, instead of destroying the bacteria, the macrophages allow them to survive and replicate within. This intracellular survival mechanism enables the infection to establish and persist in the host.

A granuloma is a specialized immune structure that forms 2-6 weeks after infection when the body initiates a cell-mediated immune response. It comprises immune cells, live and dead bacterial cells, T-cells, and macrophages clustered together. The granuloma's primary function is to contain and prevent the spread of Mycobacterium tuberculosis throughout the body.

In latent tuberculosis infection, bacteria remain dormant within the granuloma, causing no symptoms and being non-contagious. Active tuberculosis disease develops when the immune system is compromised, allowing bacteria to multiply and spread, causing tissue damage and symptoms. About 5-10% of individuals with latent TB infection progress to active disease, particularly if their immune system becomes weakened.

Caseation occurs when the center of a granuloma becomes necrotized, forming a cheese-like substance called caseum. If this caseous material erodes into a bronchus, it creates a cavity that facilitates rapid bacterial proliferation. This cavitation process worsens symptoms and increases the potential for bacterial spread through blood or lymph.

Tuberculosis transmission begins when a person inhales droplet nuclei containing Mycobacterium tuberculosis. These droplets are typically released into the air when an individual with pulmonary or laryngeal TB coughs, sneezes, or speaks. The inhaled bacteria then reach the alveoli in the lungs, where the infection cycle begins.

Approximately 2-6 weeks post-infection, the body mounts a cell-mediated immune response where T cells recognize mycobacterial antigens presented by infected macrophages. This triggers cytokine release, activating other immune cells and processes that lead to granuloma formation. This immune response aims to contain bacterial spread and is essential for controlling the infection.

Yes, from the lungs, Mycobacterium tuberculosis can spread through the bloodstream, causing miliary TB, or through the lymphatic system to other organs, resulting in extrapulmonary tuberculosis. This dissemination occurs when bacteria escape the primary infection site and establish secondary infections in various body systems, complicating the disease presentation and nursing management and prevention strategies.