Nrf2 Keap1 Pathway

The Nrf2-Keap1 pathway is a cellular defense system that regulates antioxidant and stress-response genes, making it important in immunity, inflammation, and infection. Under normal conditions, Keap1 binds Nrf2 and directs it for ubiquitination and proteasomal degradation; oxidative or electrophilic stress modifies Keap1, allowing Nrf2 to accumulate, enter the nucleus, and activate antioxidant response element (ARE)-controlled genes. These responses help maintain redox balance, limit inflammatory damage, and influence how host cells respond to microbial pathogens. Studying the pathway supports research into host-pathogen interactions and potential therapies for infectious, inflammatory, and oxidative-stress-related diseases.

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JoVE Core - Biology

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