Nanoparticle Therapy
Nanoparticle Therapy - Related Videos
08:03
Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
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Cited by 7 •
2016
Photodynamic therapy (PDT) is an alternative choice for lung cancer treatment. To increase the therapeutic effect of PDT, lung cancer-targeted nanoparticles combined with chemotherapy were developed. Both in vitro and in vivo anticancer efficacies of PDT with prepared nanoparticles were evaluated.
09:45
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
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Cited by 2 •
2015
This protocol describes a method for the fabrication of conducting polymer nanoparticles blended with fullerene. These nanoparticles were investigated for their potential use as a next generation photosensitizers for Photodynamic Therapy (PDT).
01:28
Focused Ultrasound-Enhanced Nanoparticle Delivery in a Mouse Model for Tumor Therapy
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2025
Begin with an anesthetized tumor-bearing mouse and shave its head.Place it in an MRI scanner integrated with the focused ultrasound system.The initial MRI scan locates the brain tumor and nearby blood vessels.Inject a contrast agent intravenously, then administer fluorescently labeled nanoparticles coated onto gas-filled microbubbles.The contrast agent and microbubbles circulate and reach the brain.Apply focused ultrasound waves to the tumor site.The ultrasound causes the microbubbles to expand...
10:51
Protocols for Assessing Radiofrequency Interactions with Gold Nanoparticles and Biological Systems for Non-invasive Hyperthermia Cancer Therapy
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Cited by 11 •
2013
We describe the protocols used to investigate the interactions of 13.56 MHz radiofrequency (RF) electric-fields with gold nanoparticle colloids in both non-biological and biological systems (in vitro/vivo). These interactions are being investigated for applications in cancer therapy.
10:16
Electroactive Polymer Nanoparticles Exhibiting Photothermal Properties
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Cited by 5 •
2016
A protocol is presented for the synthesis and preparation of nanoparticles consisting of electroactive polymers.
FAQs
Surface properties can change how nanoparticles behave in the bloodstream and interact with cells. Because these surfaces are modifiable, researchers can adjust them to influence circulation and uptake rather than treating particle size as the only design variable. These effects matter when the goal is to improve delivery to diseased tissue while limiting unwanted exposure elsewhere.
Responsive release mechanisms connect drug liberation to local conditions such as pH or enzyme activity. A nanoparticle can retain an active compound until it encounters a relevant biological environment, where the trigger promotes release. This design may improve delivery at the intended site and help address systemic toxicity, although performance depends on matching the carrier to local tissue conditions.
Encapsulation, binding, or chemical attachment can place an active compound within or on a nanoscale carrier. These arrangements may help manage compounds that dissolve poorly or degrade rapidly before reaching diseased tissue. The carrier therefore becomes part of the therapeutic design, influencing how the agent is transported, protected, and ultimately released in the body.
Design requires coordinating the active compound with the nanoparticle's size, surface characteristics, carrying arrangement, and release behavior. These features can affect circulation, cellular uptake, response to local conditions, and exposure to healthy tissue. Researchers must therefore balance delivery performance with the need to reduce systemic toxicity and achieve a clinically useful treatment outcome.
Evaluation focuses on whether the system delivers its active compound appropriately and responds as intended to relevant local conditions. Researchers examine factors such as circulation, cellular uptake, release behavior, and effects on diseased tissue. These observations help determine whether the design improves therapeutic delivery while addressing limitations such as poor solubility, rapid degradation, or systemic toxicity.
Medical applications include targeted drug delivery, cancer treatment, imaging-guided care, and delivery of nucleic acids. Its value differs across these uses: a system may be designed to improve access to diseased tissue, support treatment decisions alongside imaging, or transport fragile therapeutic material. These applications illustrate why nanoparticle design remains central to translating nanomedicine into safer, more precise therapies.