Menopause Research
Menopause Research - Related Videos
01:28
Menopause
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2024
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
06:18
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
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Cited by 4 •
2019
Clinically, estrogen deficiency in menopausal women may aggravate the incidence of lipid disruption and atherosclerosis. We established an in vivo estrogen deficiency model by bilateral ovariectomy via a double dorsal-lateral incision in apoE-/- mice. The mouse model is applicable for screening exogenous estrogen treatments of cardiovascular dysfunction after menopause.
14:26
A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
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Cited by 16 •
2014
Two exercise paradigms were tested on a newly developed chemically induced menopausal mouse model to examine the impact of menopause on exercise capacity and cardiac adaption to exercise.
08:04
Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
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Cited by 8 •
2014
The protocol reported here allows the evaluation of the efficacy of photodynamic therapy (PDT) in cell lines and the optimization of the PDT settings before applying the therapy in animal models.
03:24
Assessing Bone Mineral Density Using Radiofrequency Echographic Multi-Spectrometry
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2026
Source:Piera Lalli1, Elisabetta Quilico1, Chiara Busso1, Marta Andrighetti1, Cristina Graziano1, Paola Pisani2, Marco A. Minetto11Division of Physical Medicine and Rehabilitation, Department of Surgical Sciences, University of Turin.2Institute of Clinical Physiology, National Research Council.This video demonstrates the radiofrequency echographic multi-spectrometry (REMS) technique for assessing bone mineral density (BMD). The patient is positioned supine, and ultrasound gel is applied to the...
FAQs
Declining estradiol changes signaling through estrogen receptors, making these receptors a central mechanistic link between ovarian hormone changes and brain function. Menopause research examines how altered receptor signaling may affect thermoregulation, sleep, mood, and cognition. This focus connects a systemic endocrine shift with specific neurological and clinical outcomes rather than treating symptoms as unrelated events.
The hypothalamic-pituitary-gonadal axis provides a framework for studying communication among the brain, pituitary gland, and reproductive organs as ovarian hormone production changes. Investigating this axis helps researchers relate endocrine regulation to brain processes, including temperature control, emotional state, sleep, and cognition. It therefore links reproductive physiology with neuroscience-based explanations of menopausal symptoms.
Research commonly examines hot flashes, sleep changes, mood alterations, and memory or other cognitive complaints. These outcomes provide clinically recognizable measures of how hormonal changes may affect nervous-system function. Studies also extend beyond immediate symptoms to consider neural resilience and brain aging, helping distinguish short-term effects from questions about longer-term neurological health.
Menopause research considers both hormone-based and nonhormonal treatments as ways to address symptoms associated with changing ovarian hormone signaling. Comparing these approaches can help clarify which outcomes are responsive to hormonal mechanisms and which may require different strategies. The findings support treatment development while keeping neurological effects, clinical symptoms, and longer-term health questions in view.
A neuroscience-focused investigation brings biological, neurological, and clinical perspectives together. Researchers can examine declining estradiol, estrogen-receptor signaling, and hypothalamic-pituitary-gonadal activity alongside symptoms involving thermoregulation, sleep, mood, and cognition. This integrated approach helps translate molecular and endocrine observations into clinically meaningful questions about symptom emergence and treatment response.
The menopausal transition provides an important context for examining whether midlife hormonal changes relate to brain aging and neural resilience. Research can connect altered estradiol signaling and neurological symptoms with broader questions about long-term brain health. This perspective expands the field beyond symptom management and supports investigation of how hormonal transitions may shape later neurological outcomes.