Amyloid Fibrils and Protein Aggregation

Amyloid fibrils are protein aggregates with a very specific structure. They are made when proteins misfold and stick together in long, ordered fibers. This structure makes them different from many other protein clumps.

Amyloid fibrils are important in biology because they are linked to protein ag...

Proteins fold into energetically-favorable structures, with their hydrophobic amino acids on the inside and their charged and polar amino acids on the outside. Some proteins fold easily on their own but many are guided to fold correctly by proteins called chaperones.

Sometimes proteins fold into incorrect shapes, often referred to as misf...