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DNA Replication and Repair
Restarting DNA Replication After Stalls
Description
DNA replication can stop before it is finished when the fork stalls. A stalled replication fork is a point where the DNA-copying machinery slows down or pauses during chromosome duplication.
Cells can restart these forks to keep copying DNA. This process helps the replication machinery move forwa...
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Transcript
While halting a replication fork, the DNA polymerase stops synthesizing nascent DNA, but the helicase continues to unwind the double-stranded DNA for a short way before dissociating. Next, replication protein A, or RPA, binds and protects this excess single-stranded DNA at the stalled fork.
The RPA-coated single-stranded DNA then recruit...
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