33.1
Around 4 billion years ago, oceans began to condense on earth while volcanic eruptions released nitrogen, carbon dioxide, methane, ammonia, and hydrog…
On Earth, around four billion years ago, a series of volcanic eruptions released gases into a water-vapor–rich atmosphere. This atmosphere was likely dominated by methane and ammonia, with smaller amounts of hydrogen and other gases.
As Earth cooled, water vapor condensed and formed oceans.
In the 1920s, scientists suggested that UV radiation or lightning could have helped small organic molecules form.
In 1952, Stanley Miller and Harold Urey tested this idea by simulating early Earth’s atmosphere and oceans in a laboratory system. Their system was based on the model of early Earth available at the time.
When electricity was applied to the system, organic molecules such as amino acids formed in a simulated early Earth environment. Scientists think these early organic molecules may also have formed near hydrothermal vents, in volcanic regions, or at meteorite impact sites.
These amino acids could later serve as the building blocks of proteins.
Next, scientists found that nucleotides can join to form short chains similar to RNA and DNA. This showed that early biomolecules may have formed from smaller building blocks.
Another class of macromolecules, called lipids, may have formed through chemical reactions on early Earth. These lipids could self-organize to form vesicles. These vesicles created an internal space that was separate from the outside environment.
This internal space may have helped concentrate molecules and support chemical reactions. This step was important for the formation of protocells.
These protocells likely contained RNA as genetic material. Scientists think that early RNA molecules may have been able to copy themselves with the help of catalytic RNA activity and pass information to later generations.
Extreme conditions on early Earth helped form these RNA-containing protocells. From these early systems, DNA-containing cells likely evolved.
View the full transcript and gain access to JoVE Core videos
Q1: What atmospheric conditions existed on early Earth around four billion years ago?
Around four billion years ago, volcanic eruptions released ammonia, methane, hydrogen, and other gases into Earth's atmosphere, which was full of water vapor. As the planet cooled, this water vapor condensed into oceans. These primordial conditions created an environment rich in chemical building blocks necessary for the formation of organic molecules and early life.
Q2: How did the Miller-Urey experiment demonstrate the formation of organic molecules?
In 1952, Stanley Miller and Harold Urey simulated early Earth's atmosphere and oceans in a laboratory apparatus. Using electricity as an energy source, they observed the formation of amino acids, the building blocks of proteins. This groundbreaking experiment showed that the environment of early Earth was conducive to the formation of biological molecules from simple inorganic compounds.
Q3: Where might amino acids have formed on early Earth besides laboratory conditions?
Scientists suggest that amino acids may have formed near hydrothermal vents in the ocean, near areas of volcanic activity, or as a result of meteorites hitting Earth. These diverse energy sources could have driven the chemical reactions necessary to synthesize organic molecules in early Earth's oceans and contributed to the emergence of life.
Q4: How did simple building blocks combine to form complex macromolecules?
Recent studies show that nucleotides can spontaneously link together to form nucleic acids, and amino acids can self-assemble into proteins. Lipids, another class of macromolecules, can self-organize and form vesicles that separate the inside environment from the outside. This self-assembly process was critical for creating the complex molecules necessary for early life.
Q5: What role did lipid vesicles play in the evolution of early cells?
Lipids self-organized to form vesicles, which created a separate internal environment distinct from the outer surroundings. This ability to separate inside from outside is a key characteristic of life. The constant environment within these vesicles likely facilitated the formation of protocells, a critical step in the evolution of life on Earth.
Q6: What genetic material did the earliest protocells likely contain?
The earliest protocells likely contained RNA as their genetic material. RNA could self-replicate and be passed on to subsequent generations, providing the hereditary information necessary for life. These RNA-containing protocells could grow and evolve, eventually giving rise to DNA-containing cells that characterize modern life.
Q7: How did extreme conditions on early Earth enable the emergence of life?
The extreme conditions on early Earth—including volcanic activity, UV radiation, lightning, and meteorite impacts—provided energy sources that drove chemical reactions. These conditions enabled the formation of organic molecules, their self-assembly into complex macromolecules, and ultimately the development of RNA-containing protocells from which DNA-containing cells evolved.