Eukaryote transcriptieremmers

Transcription inhibitors are capable of repressing the transcription of a gene. They have a distinct domain that binds to regulatory sequences on DNA and another domain that represses transcription.

These proteins can inhibit transcription through various mechanisms. The simplest one is by blocking an activator from binding to its cis-regulatory sequence, through one of several different mechanisms.

In some cases, the inhibitor competitively binds to the regulatory sequence, thereby preventing the binding of the activator. In others, the inhibitor binds to a site near the activator binding site, and its repressor domain interacts with the activator to prevent it from binding to the regulatory sequence.  

An inhibitor can also bind competitively to the binding sites of general transcription factors on the DNA and block the assembly of the transcriptional machinery.

Inhibitors can also bind to their own inhibitory cis-regulatory sequences, preventing the initiation of transcription even in the presence of an activator on the regulatory region.

One of the most common mechanisms used by transcription inhibitors is to use its repressor domain to recruit proteins known as co-repressors.