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JoVE Core
Pharmacology
Drug Dependence
Video Quiz
Drug Dependence
JoVE Core
Pharmacology
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JoVE Core Pharmacology
Drug Dependence

2.2: Drug Dependence

1,824 Views
01:17 min
September 22, 2023

Overview

Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug significantly influence the individual's desire for repeated use, potentially leading to relapse. In contrast, physical dependence involves the manifestation of withdrawal or abstinence symptoms when the drug is suddenly stopped or an antagonist is introduced. This disruption interferes with the body's homeostatic balance.

Take nicotine, a main ingredient in tobacco, as an example. It can cause both psychological and physical dependency. A person trying to quit smoking may experience withdrawal symptoms. Successfully managing these symptoms may allow temporary cessation of smoking. However, over time, feelings of depression and psychological cravings may arise, leading to a relapse.

Transcript

Drugs are generally prescribed to produce therapeutic effects.

Certain drugs are capable of altering an individual's mood and perception, often generating different kinds of pleasurable experiences. This may lead to drug dependence—a state of compulsive and persistent drug use with possible adverse effects.

Drug dependence can be categorized as psychological dependence or physical dependence.

In psychological dependence, the drug-induced rewarding experience can strongly influence the person's desire to repeat the high and relapse. 

In physical dependence, a person experiences withdrawal or abstinence symptoms if the drug is abruptly discontinued or an antagonist is administered. This disturbs the homeostatic set point.

Nicotine, an active ingredient in tobacco, has psychological and physical dependence.

A person trying to quit smoking may experience withdrawal symptoms. If these symptoms are overcome, the person might be able to quit smoking temporarily. However, with time, depression and psychological cravings develop, which leads to relapse. 

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Drug DependenceMedicationsTherapeutic EffectsMood ModificationPsychological DependencePhysical DependenceWithdrawal SymptomsAbstinence SymptomsNicotineTobaccoRelapseCravingsHomeostatic Balance

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