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Method Article

Performing Electroconvulsive Therapy and Assessing Seizure Efficacy via Pupillary Response

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August 29th, 2025

In This Article

Abstract

Source: Shirozu, K., et al. Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy. J. Vis. Exp. (2019)

This video demonstrates the procedure for performing electroconvulsive therapy in a human patient, highlighting the stimulation process and assessing seizure activity through pupillary response.

Protocol

All procedures involving human participants have been performed in compliance with the institutional, national, and international guidelines for human welfare and have been reviewed by the local institutional review board.

1. Electroconvulsive Therapy Procedure

1. Conduct electroconvulsive therapy (ECT) via bitemporal electrode stimulation using an ECT instrument. Set the initial electrical stimulus dose (%) at half the value of each individual’s age.
NOTE: Maximum stimulus dose is 100%. The electrical stimulation time is about 7-8 s.

2. Immediately after electrical stimulat....

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Results

EEG seizure analysis; diagram displaying postictal suppression index and seizure criteria evaluation.

Figure 1. Electroencephalogram (EEG) results during a typical seizure.

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Materials

List of materials used in this article
NameCompanyCatalog NumberComments
Npi-100/automated infrared pupillometerNeurOptics
Electroencephalogram (EEG)Somatics Inc.ECEF-4
Npi-200/automated infrared pupillometerNeurOptics

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