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Method Article

High-Definition Transcranial Direct Current Stimulation for Activation of the Target Brain Region

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August 29th, 2025

In This Article

Abstract

Source: Chen, W., et al. Stimulation Location Determination using a 3D Digitizer with High-Definition Transcranial Direct Current Stimulation. J. Vis. Exp. (2019)

This video demonstrates the procedure for delivering high-definition transcranial direct current stimulation (HD-tDCS) by accurately positioning electrodes using the 10–10 system, mapping their locations with a 3D digitizer, and applying stimulation to modulate neuronal activity in a targeted brain region.

Protocol

All procedures involving human participants have been performed in compliance with the institutional, national, and international guidelines for human welfare and have been reviewed by the local institutional review board.

  1. Stimulation
    1. Make sure that the participants have no contraindications (e.g., a history of neurological or psychiatric disorders) for HD-tDCS (high-definition transcranial direct current stimulation) and that they provided written informed consent prior to the study (including HD-tDCS stimulation).
    2. Ensure that all the necessary materials are available for device i....

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Results

Transcranial DC stimulation setup with multichannel adapter, electrodes, batteries, and conductive gel.

Figure 1: Necessary materials for stimulation. These materials include a tDCS device, a 4x1.......

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Materials

List of materials used in this article
NameCompanyCatalog NumberComments
1X1 Low intensity transcranial DC stimulatorSoterix Medical1300A
3-Dimensional Polhemus-Patriot digitizerPOLHEMUS1A0453-001PATRIOT system component
4X1 Multi-channel stimulation interfaceSoterix Medical4X1-C3
Dell desktop computerDellCRFC4J2Master computer to run 3D digitizer application

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