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investigating the immunological mechanisms underlying organ transplant rejection

Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection

My Name is Sang Mo Kang of the UCSF Department of Surgery. I'm a transplant surgeon. My work is trying to understand the immunology underlying transplant rejection.Mechanistic studies are are best performed in road models as there is. It's very difficult to perform these types of studies in humans for obvious reasons. The models that we use are useful for trying to understand the mechanisms, which can then lead to potential development of therapies for human use.But there would need to be a translation of this work often into primate models before going to human Trials. The Heterotopic heart transplant is performed by placing the donor heart into the abdominal cavity of the recipient. The donor aorta is hooked up to the abdominal aorta of the recipient.The donor pulmonary artery is then anastos to the inferior vena cava of the recipient. The heterotopic heart transplant model is a useful model for transplant immunology because unlike skin transplants, which are very, very difficult to obtain, tolerance to heart transplants are a little bit easier to prolong transplant survival using a variety of techniques. So it serves as a useful assay of the overall immune response to Transplant

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JoVE Journal

Biology

University of California, San Francisco - UCSF.  Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection

Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection

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