Transplant Surgery
Transplant Surgery - Related Videos
14:03
Orthotopic Hind-Limb Transplantation in Rats
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Cited by 21 •
2010
Here we describe the orthotopic rat hind-limb transplantation procedure, which seems to be the gold standard in vivo model for composite tissue allotransplantation research.
07:59
Murine Full-thickness Skin Transplantation
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Cited by 41 •
2017
Murine full-thickness skin transplantation is a well-established model to study rejection in an alloimmune setting. Here, we provide a tutorial of each step involved in performing a BALB/c-->C57BL/6 full-thickness skin transplant.
11:29
A Modified Method for Heterotopic Mouse Heart Transplantion
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Cited by 5 •
2014
A technique is demonstrated for the microsurgical procedure for heterotopic transplantation of hearts in mice, including simplified methods for donor harvesting and recipient vessel anastomosis.
08:58
Murine Kidney Transplant Technique
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Cited by 8 •
2015
The goal of this manuscript is to describe the steps required to perform a kidney transplant in a mouse, paying particular attention to the details of the arterial anastomosis.
36:30
Small Bowel Transplantation In Mice
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Cited by 2 •
2007
The mouse small bowel transplantation model has been recognized as an important tool to study mechanismes of immune rejection and screen new immunosuppressive drugs. However, this model is limited to use because the techniques involved is an extremely technically challenge. Now we introduce the modified technique.
FAQs
Rejection develops when the recipient’s immune system recognizes donor tissue as foreign. This immune response can damage the graft and reduce its ability to perform its biological function. Immune compatibility therefore becomes a central determinant of graft survival, linking transplant outcomes directly to immunology rather than to surgical repair alone.
Donor matching helps reduce biological differences between donor material and the recipient. Greater immune compatibility can lower the likelihood that the recipient will identify the graft as foreign and initiate rejection. Matching is therefore paired with immunosuppressive therapy, creating two complementary strategies for protecting graft function after transplantation.
Surgical connection of blood vessels allows the transplanted material to participate in the recipient’s circulation, while connections between other tissues help restore structural and functional continuity. These repairs are essential because organ physiology depends on coordinated tissue function. Successful biological integration therefore requires more than placing donor material in the recipient.
A transplant workflow includes selecting suitable donor material, surgically placing it in the recipient, connecting blood vessels and other relevant tissues, and managing immune compatibility afterward. Preservation supports the donor material before implantation, while immunosuppressive therapy helps limit rejection. Together, these stages address surgical integration, biological function, and immune protection.
Preservation helps maintain donor material before it is implanted, whereas immunosuppressive therapy acts after transplantation to reduce harmful immune responses. These measures address different stages of the process: one protects the material before surgery, and the other supports its survival in the recipient. Both aim to improve graft survival and reduce complications.
Transplant surgery provides a practical setting for studying immunology, tissue repair, and organ physiology. Research examines donor matching, preservation, immunosuppressive therapy, and regenerative approaches to improve graft survival and reduce complications. Regenerative strategies are especially relevant to expanding access to replacement organs, complementing conventional transplantation rather than focusing only on surgical technique.