Here we present the case of a patient who experienced an iatrogenic common bile duct transection during a routine laparoscopic cholecystectomy for cholelithiasis at a rural resource-limited institution. If the hospital had hepatobiliary expertise, direct repair or reconstruction with Roux-en-Y hepaticojejunostomy would have been indicated for this major BDI (based on Strasberg classification) discovered intraoperatively. No hepatobiliary surgeons were available at the operating hospital to assist in the repair of the BDI. In this situation, WSES guidelines suggest drain placement and referral to another center with hepatobiliary experience within 0-48 h13. However, given the unique circumstances, as this case occurred during the COVID-19 pandemic, hospital bed availability was scarce. The patient would have either had to wait multiple days for admission to a tertiary institution or be treated with limited resources at the operating facility without advanced gastrointestinal capabilities. Fortunately, telemedicine changed the course of this case.
In terms of reconstructive outcomes, there are many considerations for the creation of the hepaticojejunostomy anastomosis, and the approach should be made on an individualized basis and based on the surgeon's experience. We performed a continuous anastomosis utilizing barbed suture. Although several suture types (e.g., V-loc and polydioxanone [PDS]) have been described, there is a lack of literature directly comparing outcomes. We favor barbed sutures as they allow for a greater amount of tension to be maintained on the suture during the anastomosis creation. In an effort to mitigate the risk of occlusion by inadvertently "backwalling," we elect to place a 4-french plastic stent during suturing, particularly when the duct is small. One study found that when a stent was used, there was no difference in the rate of anastomotic stricture, although further study is warranted to better understand outcomes when an intraductal stent is employed21. Another alternative approach to consider is performing an interrupted suturing technique during anastomosis creation. Multiple recent randomized trials and one meta-analysis have shown no difference in overall biliary complications, including bile leak, biliary stricture, cholangitis, or liver abscess22,23,24. Consistently reported, however, are statistically significant increased material costs and operative time when interrupted suturing is performed.
The incidence of anastomotic stricture in the literature is relatively common, with many citing 20%, but has been reported as high as 69%25. One meta-analysis of 17 studies found concomitant vascular injury (OR 4.96; p = 0.001), post-repair bile leak (OR 8.03; p = 0.003), and repair by a nonspecialist surgeon (OR 11.29; p < 0.0001) are predictors of anastomotic stricture26. Interestingly, in patients undergoing pancreaticoduodenectomy, multiple studies have shown smaller duct size to be predictive of anastomotic stricture. One retrospective cohort study analyzing 241 operative videos found that the duct size of ≤10 mm was 12x more likely to develop stricture and/or cholangitis than larger ducts (p = 0.018)21. Another retrospective study of 103 patients found that duct diameter <6 mm was significantly more likely to stricture than those ≥6.0 mm (25.9% vs 1.3%, p < 0.01)27. Our patient was unfortunately diagnosed with a short-segment stricture without cholangitis in the setting of abdominal pain and elevated liver enzymes, requiring ERCP with covered metal stent placement. The anastomosis was found to be patent on follow-up endoscopic assessment with improved hepatic function studies. He is monitored clinically and biochemically without evidence of recurrence.
Telemedicine has existed in various forms since the inventions of the telephone and radio made it possible for clinicians to provide medical advice to distant colleagues and patients28. Since that time, it has expanded to include a wide array of modalities. Noted benefits of telemedicine for patients include access to clinicians in distant locations, avoidance of spreading communicable disease, and reduced expenses accruing from travel, childcare, or lost work29. Telemedicine is limited in its uses; however, in some cases, due to its lack of in-person care. Despite limitations, telemedicine spiked during the COVID-19 pandemic. This trend was also seen specifically in surgical specialties, as one review concluded that surgical specialties heavily utilized and published articles about the use of telemedicine during this time30. Most commonly, telemedicine is useful for surgical patients who live too far to easily access post-surgical clinic visits.
Another modality of telemedicine, intraoperative consultation, is utilized less commonly in surgery. In the case presented here, intraoperative video consultation uniquely enabled a hepatobiliary surgeon at our tertiary institution to directly visualize the transected bile duct and provide management recommendations in real time. Once BDI was confirmed with a cholangiogram, it became clear that expedited transfer to our academic center was necessary for optimal management. The consultant recommended against converting to a laparotomy and advised the operating surgeon to place an abdominal drain to limit intra-abdominal contamination. This decision was made so that reconstruction with a hepaticojejunostomy could be performed with a robotic approach. While waiting for OR transfer, a CT angiogram was recommended to rule out the possibility of vascular injury. Collectively, these recommendations allowed the patient to be a candidate for direct to operating room (OR) transfer, a process which has long been known to reduce morbidity and mortality in a range of severely injured patients31. A quick referral was crucial, as a late referral to a tertiary center after BDI is an independent prognostic factor for a worse outcome32. Alternatively, had consultation been delayed until after the operation was completed, the initial focus would have been on confirming and characterizing the injury. A several-day wait for a hospital bed would have ensued, and ERCP or percutaneous transhepatic cholangiography with interventionalist colleagues would have further contributed to the delay. This undoubtedly would have placed the patient outside the window in which early reconstruction was favorable due to ongoing intraabdominal contamination and post-surgical inflammation. Overall, this case showcases the value of a relatively novel use of telemedicine via intraoperative consultation. To our knowledge, there has been only one other case reported in which real-time intraoperative, suggesting the unrealized potential to improve patient care in these difficult circumstances33.
Finally, the rural area where this BDI occurred played a significant role in the case. It took place in West Virginia, where the 2020 United States Census reported 55.4% of people live in rural areas, making it the third most rural state34. Fifty-one of West Virginia's 55 counties are considered Health Professions Shortage Areas (HPSAs) or Medically Underserved Areas (MUAs), causing patients to have to travel great distances to receive care35. Thus, it is unsurprising that a facility and surgeon with hepatobiliary expertise were locally unavailable to the patient. This limited access to healthcare is also a likely contributor to West Virginia's status as one of the unhealthiest states. These combined factors place West Virginians in a difficult position in which they are more likely to have a high burden of comorbidities and less likely to access care. Though a multifactorial problem requiring many solutions, telemedicine can ease this burden for patients and local physicians by providing rapid access to care and peer consultation, as occurred in this case. One study in which specialists remotely telementored or telerobotically assisted colorectal surgeries at rural hospitals concluded that this was an effective method for providing community surgeons with advanced training in surgical techniques and providing immediate management advice if surgical complications arose. This further increased surgical confidence and breadth of surgical procedures performed at community hospitals36. Broader implementation of similar strategies would likely benefit all rural areas.
This case provides a unique example of how excellent communication across surgeons in different rural areas led to the rapid discovery and repair of a complete bile duct transection during laparoscopic cholecystectomy. It highlights the benefits of telemedicine, specifically intraoperative video consultation. Here, consultation resulted in an expedited intraoperative patient "workup" that allowed for direct to OR transfer, which would not have been possible otherwise due to the COVID-19 pandemic. This case also emphasizes how intraoperative consultations can be especially beneficial to rural hospitals that may not have access to a wide range of surgical specialists. Together, this unique sequence of events and multi-hospital interprofessional collaboration resulted in efficient repair of the patient's BDI.