Guest Editors
Victoria Tovell
University College London,Institute of Ophthalmology,Development, Ageing and Disease
Dr Victoria Tovell is a stem cell biologist working as a research fellow at the Institute of Ophthalmology (IoO), University College London. She was awarded her PhD in Cell Biology from the University of East Anglia, UK where she researched purinergic signalling in human retinal pigment epithelial cells (RPE). Since then, she moved to the IoO where her research has continued in field of ocular disease. Her current research focusses on developing stem cell therapies for the treatment of age-related macular degeneration with a specific interest in producing a tissue engineered vasculature for transplantation.
Loriana Vitillo
University College London,Institute of Ophthalmology,Development, Ageing and Disease
Dr. Loriana Vitillo is a research associate at the Institute of Ophthalmology, University College London, working on the London Project to Cure Blindness with Prof. Pete Coffey. Loriana has worked in the field of pluripotent stem cells and regenerative medicine for 10 years and authored several peer-reviewed publications and policy papers. She holds a PhD from the University of Manchester where she studied mechanisms of integrin signalling in pluripotent cells. She then moved to the Cambridge Stem Cell Institute as a postdoc leading a multidisciplinary translational research project as part of the UK Regenerative Medicine Platform. Alongside her academic activity, Loriana is focused on making an impact through science communication having produced an award-winning documentary and game about stem cell research.
Collection Overview
Regenerative medicine, although rapidly progressing, remains a young field facing unique translational challenges. To achieve tissue and organ regeneration, research is focused on stem cells and gene-based therapies, tissue engineering and more recently regenerative small molecules. It has become apparent that an effective regenerative therapy relies not only on replacement of a specific cell type, but also incorporation within the surrounding architecture of the diseased tissue.
The eye presents as a model organ which drives regenerative medicine forward, due to its structure, immune-privileged status and ease of access. From the retina to the cornea, ocular research is at the forefront of regenerative medicine. Ocular translational research has provided unprecedented insight into the challenges ahead for the repair of more complex organs. For example, stem cell-based clinical trials for age related macular degeneration, a rapidly progressive disease, show how crucial it is for the transplant to be structurally, functionally and timely delivered. Ophthalmology is advancing regenerative medicine towards approaches that are multidisciplinary and highly disease-oriented, including engineering of multicellular tissue architectures and robotic precision delivery.
The aim of this collection is to bring together novel multimodal approaches in regenerative therapies for ocular diseases spanning the whole structure of the eye.
Articles
Production of Modified Autologous Conditioned Serum and Ex Vivo Assessment of Its Healing Potential in Murine Corneal Epithelium
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Cited by 3
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2023
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Chun Hsiung*1,2, Yu-Ting Liu*1,2, Chen-Ying Su3, Chung-Chuan Hsiung4,5, Kuo-Hsuan Hung2,6,7, Lung-Kun Yeh2,6
1Department of Education, Chang Gung Memorial Hospital Linkou, 2School of Medicine, Chang Gung University, 3Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, 4Cell Therapy Center, Tri-Service General Hospital, 5Department of General Surgery, Bo-Ai Clinic, 6Department of Ophthalmology, Chang Gung Memorial Hospital Linkou, 7Institute of Clinical Medicine, National Yang Ming Chiao Tung University