Guest Editors
Hao Li
China Agricultural University, College of Veterinary Medicine
Dr. Li earned his bachelor’s degree from Henan Agricultural University in 2008. He received his master’s degree in Science from Academy of Military Medical Sciences in July, in 2011. Post his master’s degree he worked as a research assistant for 2 years at School of Medicine, Tsinghua University. He received his PhD degree in 2017, from Tsinghua University. After graduating, he worked as a post-doctoral fellow for 2 years at Tsinghua university in School of Medicine. Since July 2019, he is working as an associate professor at China Agricultural University, in College of Veterinary Medicine. His research interests are focused on the topics of tuberculosis immunology and antibiotics resistance.
Wenping Gong
The 8th Medical Center of Chinese PLA General Hospital, Senior Department of Tuberculosis, Wuhan, China
Dr. Wenping Gong completed his bachelor’s degree from Wuhan University in 2010. He further obtained his PhD degree from Academy of Military Medical Sciences, Beijing, China. He has been serving as an assistant professor at the 8th Medical Centre of Chinese PLA General Hospital. His work focuses on developing novel peptide vaccines for TB and differential diagnostic reagents for latent tuberculosis. He has contributed more than 30 valuable publications in different scientific journals indexed by SCI database. He has been invited as reviewers for 6 international journals, editorial members for 2 journals, and committee members for Chinese Research Hospital Association, Chinese Antituberculosis Association, and Beijing Anti-Tuberculosis Association.
Mao-Shui Wang
Shandong University, Shandong Provincial Chest Hospital, Department of Lab Medicine, Shandong, China
Dr. Wang is currently working as an associate professor at Shandong Provincial Chest Hospital. Before joining the hospital, he completed his master’s degree within the Department of Lab Medicine at the Guangxi Medical University. Now, he is pursuing his M.D. at Department of Paediatrics at the Shandong University. His primary research interests include tuberculosis and pleural diseases, particularly childhood tuberculosis. He has published about 40 papers in peer-reviewed journals and has also served as an Editorial Board Member for several journals, including BMC Pulmonary Medicine, BMC Pediatrics, Journal of Tropical Medicine, and Therapeutic Advances in Infectious Diseases.
Xia Yu
Capital Medical University, Beijing Chest Hospital, Beijing Key laboratory for Drug-resistant Tuberculosis Research, National Clinical Laboratory on Tuberculosis, Beijing, China
Dr. Yu pursued her bachelor’s degree in Medicine from China Medical University in 2007. She pursued her master’s degree in medicine from Beijing Tuberculosis and Thoracic Tumor Research Institute in 2011. She then worked as a research assistant for a period of 4 years at the Beijing Tuberculosis and Thoracic Tumor Research Institute. She completed her PhD degree in Science from Peking Union Medical College in 2019. Post her PhD degree, she is working as an associate professor in the Beijing Chest Hospital, at Capital Medical University.
Collection Overview
Tuberculosis (TB) is an important zoonosis and a global public health problem. The etiological agent causing TB is one of the several mycobacterial species belonging to the Mycobacterium tuberculosis (Mtb) complex, which is an intracellular pathogen. Mtb infection can arouse host innate and adaptive immune responses when entering the body. Innate immunity has an important role against Mtb infection. Airway Epithelial cells, macrophages, neutrophils, dendritic cells (DCs), natural killer cells (NK), mast cells and complement are the major components of innate immunity. The adaptive immunity including the cellular and humoral immune responses which also play important roles against TB. However, although we know the importance of innate and adaptive immune responses against Mtb, the mechanisms behind this need be further elucidated.
The only licensed vaccine for tuberculosis is BCG vaccine, however, BCG can only attain partial protection against tuberculosis in children. There is an urgent need for new vaccine development around the world. The current TB vaccine development are mainly based on the following strategies: attenuated live vaccines, subunit vaccines, viral vector vaccines and inactivated vaccines. Although M72/AS01E candidate has achieved 49.7% efficacy in TB prevention, there are still some challenges ahead for vaccines research and development. (1) can we find more and better animal models for TB vaccines efficacy evaluation? (2) Elucidate the protective mechanisms of the vaccine candidates including the cellular and antibodies immune responses; (3) how to improve the efficacy of vaccines licensed and in clinical trials? (4) Develop a better efficacy, more cost-saving, safety, and availability TB vaccine.
Articles
Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria
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Cited by 2
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2023
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Praapti Jayaswal1, Mohd Ilyas1, Kuljit Singh1,2, Saurabh Kumar1,3, Lovely Sisodiya1, Sapna Jain1, Rahul Mahlawat1, Nishant Sharma1,4, Vishal Gupta1, Krishnamohan Atmakuri1
1Bacterial Pathogenesis Laboratory, Infectious Diseases and Immunology Group, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 2Clinical Microbiology Division, CSIR-Indian Institute of Integrative Medicine, 3ICAR-Research Complex for Eastern Region, 4Public Health Research Institute, Rutgers University