Organoid models, either generated from primary cells or induced pluripotent stem cells, have tremendous potential to allow us to learn more about various tissues of interest in both health and disease. However, a major difficulty in utilizing these models is that organoids are heterogeneous, both in terms of size and shape, and their complex three-dimensional structure makes them difficult to assay.

The incorporation of organoids/cells derived from organoids into small micrengineered Chips represents one way in that some of these difficulties may be overcome. This allows a consistent number of cells to be studied and generally permit access to the apical and luminal aspect of the tissue of interest. In addition, they may allow continuous media flow, which recreates various in vivo physiological conditions and also the incorporation of additional cell types that permit cell-cell interactions to be studied.

The goal of this collection to bridge the gap between the two technologies and demonstrate how such organoids/cells derived from organoids are incorporated into these systems. Also, methodologies to assess how are cells are assayed in these systems will be included also.