Existence of adult neurogenesis throughout lifespan is recurrently challenged with conflicting results. This is particularly the case with studies using non-human primates and human tissues.  One possible roadblock to study and assess adult neurogenesis in these species could be the access to pristine tissue, another could be a lack of shared methodologies and techniques between laboratories. With the rate of adult neurogenesis decreasing during ageing, it will be beneficial to standardize methods to improve translatability of results to clinical settings.

This collection aims at collating protocols to advance adult neurogenesis research by highlighting processes to isolate and use hippocampal tissue for immunohistochemistry, high-throughput studies (e.g., RNA-sequencing) and for investigating signalling pathways (e.g., lipids metabolism, ROS) involved in modulating the rate of adult neurogenesis. Furthermore, it will focus on in vivo methods, such as advanced techniques in labelling and behavioural studies to assess the link between adult neurogenesis and cognitive functions.