
Tang-Chuan Wang
China Medical University Hsinchu Hospital in Taiwan, Department of Otolaryngology-Head and Neck Surgery
Dr. Tang-Chuan Wang (MD, Ph.D., FACS) is an otolaryngologist. He currently serves as chairman in the Department of Otolaryngology-Head and Neck Surgery at China Medical University Hsinchu Hospital, Taiwan. He specializes in minimally invasive surgery (including endoscopic, robotic, and navigation surgery). He was a research scholar at Harvard Medical School, MA, and University of Iowa Hospitals, IA, and is a Fellow of the American College of Surgeons. During his substantial clinical experience, Dr. Wang has worked at Stanford University, the University of Pennsylvania, Boston Childrens' Hospital, and Massachusetts Eye and Ear and has collaborated in research and clinical projects. He believes that the auditory system is one of the finest structures in the human body. When people communicate with others, listening is always the first step. That is why Helen Keller once said, "Blindness separates people from things; deafness separates people from people". In addition to clinical and basic research, Dr. Wang also launched out into public health in Taiwan. Public health has been defined as "the science and art of preventing disease", improving quality of life through organized efforts. He believes that we must integrate precision medicine, preventive medicine, and telemedicine into one module in order to develop comprehensive, multifaceted strategies to address public health needs. In recent years, Dr. Wang has devoted himself to these fields and further medical innovations. He always says that "in theoretical or practical aspects, no innovation is a step backward ". Due to his contribution to bio-design, he was invited to join the executive committee of the Advanced Joint R & D Center in Taiwan.

Tzu-Ching Shih
China Medical University in Taiwan, Department of Biomedical Imaging and Radiological Science, College of Medicine
Tzu-Ching Shih received his PhD in mechanical engineering from the National Taipei University of Technology and Tatung University, Taipei, Taiwan. From 2003-2004, he was a postdoctoral researcher in the Institute of Biomedical Engineering, which belongs to the College of Medicine and College of Engineering, National Taiwan University. In 2005, he joined the faculty of China Medical University as an Assistant Professor at the Department of Medical Radiological Technology. He was promoted to Associate Professor in 2007. From July 2008 to September 2009, he was a visiting Research Associate at John Tu and Thomas Yuen Center for Functional Onco-Imaging, the University of California at Irvine. He was the Director of the Department of Biomedical Imaging and Radiological Science from 2013 to 2017 and was the Director of the Beigang Campus from 2017 to 2018, China Medical University. His research focuses on fundamental engineering disciplines such as thermodynamics, fluid mechanics, and acoustics in medicine. He was promoted to Professor of the Department of Biomedical Imaging and Radiological Science at China Medical University, Taiwan in 2014. Professor Shih has broad research interests. His recent research includes computer methods and programs in biomedicine, computational fluid dynamics simulation in medicine, medical image analysis for computer-aided diagnosis and therapy, high-intensity focused therapeutic ultrasound, and thermal dose calculation of hyperthermia in oncology.
Noise-induced hearing loss (NIHL) is a serious health problem that affects quality of life and imposes a significant healthcare burden worldwide. NIHL is a complex disease influenced by sex, age, underlying diseases, genetics, physical and chemical hazards, and personal behaviors. Although NIHL is primarily caused by loud sound damage, moderate and cumulative chronic noise overexposure has also been associated with hearing difficulties such as tinnitus. NIHL studies are challenging because cochlear synaptopathy, a result of noise damage, can avoid detection in standard clinical diagnostics. Furthermore, understanding the perceptual consequences of cochlear synaptopathies requires correlating physiological measures of synaptopathy with measures of auditory perception in the same individual. While animal models of NIHL have helped elucidate the pathophysiology of NIHL, behavioral and perception measures are difficult to perform in animal models.
Recent developments in NIHL research include the identification of putative pathways involved in NIHL and the development of potential medications against these molecular targets. Evaluation of the efficacy of these emerging therapies requires the establishment of sensitive and specific assays or non-invasive measures. Machine learning-based approaches to develop new algorithms and models for NIHL predictions have emerged, and computer simulations of sound transmission in the ear and finite element models have been used to develop artificial ossicles, hearing aids, and hearing protection devices.
This collection will focus on specialized methods, assays, and tools developed for NIHL research. Research areas including (but not limited to) basic science, clinical research, and computation modeling methods are welcome.
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2023
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1Department of Neurobiology, University of Pittsburgh, 2Center for Neuroscience, University of Pittsburgh, 3Department of Bioengineering, University of Pittsburgh, 4Center for Neural Basis of Cognition, University of Pittsburgh, 5Department of Communication Science and Disorders, University of Pittsburgh, 6Department of Transfer and Innovation, USC University Hospital Complex (CHUS), University of Santiago de Compostela