
Large animal research is an essential step in the translational science spectrum. Due to their size, anatomic and physiologic similarities, genetic diversity, etc., large animals such as dogs, pigs, and sheep, etc., offer several benefits to evaluate basic science findings further and bring those discoveries closer to the clinical world. In addition, novel interventions and treatments can be assessed in those models while caring for the animals in environments that closely replicate clinical care. However, large animal research is inherently complex, which can introduce variability, potentially compromising the data’s rigor and reproducibility.
This issue will present several large animal models of cardiovascular disease. We seek for the models described in this issue to be shared with the scientific community in sufficient detail to facilitate reproducibility and enhance access to cutting-edge large animal models.
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Cited by 4
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2022
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1Department of Biomedical Engineering, University of Utah, 2Department of Emergency Medicine, University of Utah, 3Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, 4Department of Anesthesiology, University of Utah, 5Geriatric Research, Education, and Clinical Centre, VAMC
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2023
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Cited by 1
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2024
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A Controlled Reperfusion Model via Extracorporeal Membrane Oxygenation in A Pig Model of Global Ischemia from Cardiac Arrest
Joseph Tonna1,
Miriam Peckham2,
M Austin Johnson3,
Scott Youngquist*3,
Guillaume Hoareau3,
Matthew Alexander2
1Department of Surgery, Division of Cardiothoracic Surgery,
2Department of Radiology, University of Utah School of Medicine,
3Department of Emergency Medicine, University of Utah
Closed chest porcine model of AF induction
Cristiano Cardoso1,
Abdelmotagaly Elgalad*1
1Texas Heart Institute
Canine Model of Ischemia-Induced Ventricular Tachycardia
Derek Dosdall*1
1University of Utah
Controlled Induction and Modulation of Blood Pressure Variability in a Rabbit Model of Ischemic Stroke
M Austin Johnson1,
Guillaume Hoareau1,
Matthew Alexander*2,
Matthew Zabriskie2,
Nitin Chakravarthula1
1University of Utah, Department of Emergency Medicine,
2University of Utah, Department of Radiology and Imaging Science
A Porcine Model of Volume Overload
Bret Alvis*1
1Vanderbilt University Medical Center
A Porcine Model for Acute Respiratory Distress
Bret Alvis*1
1Vanderbilt University Medical Center