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TOPICAL COLLECTIONS

Large Animal Models in Biomedical Research: Accelerating Translation to Clinical Discoveries

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Guest Editor

Guillaume Hoareau

Guillaume Hoareau

Nora Eccles-Harrison Cardiovascular Research and Training Institute, Department of Emergency Medicine

Dr. Hoareau earned his veterinary degree from the Toulouse National Veterinary School, France. He is board-certified by both the American and European Colleges of Veterinary Emergency and Critical Care. Dr. Hoareau holds a Ph.D. from the University of California-Davis in Integrative Pathobiology, specifically in resuscitation and hemorrhage control. He was a research fellow in trauma and critical illness in collaboration with the United States Air Force with a focus on large animal translational science. He is now an Assistant Professor with the Emergency Department and an investigator at the Nora Eccles-Harrison Cardiovascular Research and Training Institute at the University of Utah. His interests include hemorrhage control, mitigation of ischemia-reperfusion injury, and mitochondrial pathobiology.    

Collection Overview

Large animal research is an essential step in the translational science spectrum. Due to their size, anatomic and physiologic similarities, genetic diversity, etc., large animals such as dogs, pigs, and sheep, etc., offer several benefits to evaluate basic science findings further and bring those discoveries closer to the clinical world. In addition, novel interventions and treatments can be assessed in those models while caring for the animals in environments that closely replicate clinical care. However, large animal research is inherently complex, which can introduce variability, potentially compromising the data’s rigor and reproducibility.

This issue will present several large animal models of cardiovascular disease. We seek for the models described in this issue to be shared with the scientific community in sufficient detail to facilitate reproducibility and enhance access to cutting-edge large animal models.

Articles

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock
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Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock

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Cited by 4

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2022

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Abstracts

A Controlled Reperfusion Model via Extracorporeal Membrane Oxygenation in A Pig Model of Global Ischemia from Cardiac Arrest

Joseph Tonna1,

Miriam Peckham2,

M Austin Johnson3,

Scott Youngquist*3,

Guillaume Hoareau3,

Matthew Alexander2

1Department of Surgery, Division of Cardiothoracic Surgery,

2Department of Radiology, University of Utah School of Medicine,

3Department of Emergency Medicine, University of Utah

Closed chest porcine model of AF induction

Cristiano Cardoso1,

Abdelmotagaly Elgalad*1

1Texas Heart Institute

Canine Model of Ischemia-Induced Ventricular Tachycardia

Derek Dosdall*1

1University of Utah

Controlled Induction and Modulation of Blood Pressure Variability in a Rabbit Model of Ischemic Stroke

M Austin Johnson1,

Guillaume Hoareau1,

Matthew Alexander*2,

Matthew Zabriskie2,

Nitin Chakravarthula1

1University of Utah, Department of Emergency Medicine,

2University of Utah, Department of Radiology and Imaging Science

A Porcine Model of Volume Overload

Bret Alvis*1

1Vanderbilt University Medical Center

A Porcine Model for Acute Respiratory Distress

Bret Alvis*1

1Vanderbilt University Medical Center