Collection-image

TOPICAL COLLECTIONS

Characterization and Application of Organ-Specific Tissue Scaffolds for Regenerative Medicine

Submit Abstract

Guest Editor

Saima Imran

Saima Imran

University of Padua Medical School, Padua University, Department of Cardiac Thoracic and Vascular Sciences and Public Health,

Saima Imran is a cell and molecular biologist at the University of Padova. Dr. Imran did her doctorate in the Biological Chemistry field at the University of Karachi, Pakistan, in 2008. Her thesis was based on screening natural and synthetic molecules for their anti-inflammatory potential using in vivo and in vitro assays. Her work has been published in peer-reviewed articles (more than 30 publications). She has been working as a Researcher at Palacky University (Czech Republic) for two years, from 2009 to 2011. She worked as a postdoctoral fellow (2011-2012) at Carl Tryggers’ scholarship at Uppsala University (Sweden). Dr. Imran was selected as a senior lecturer for the Mobility Grant at Palacky University (Czech Republic) from 2013 to 2015. This initiative grant was to establish Stem cell-based research at the Department of Cell Biology and Genetics, her research project was to determine the mechanism of AhR receptor expression, and its target genes in hiPSCs derived motor neurons. During this period, she also visited University College London (May 2014-September 2014) to get research experience in the human embryonic stem cell (hESCs) and hiPSCs cells differentiation. There she worked at the Institute of Child Health. From 2016 to 2018, she worked as a Postdoctoral fellow at the Venetian Institute of Molecular Medicine, Italy. Currently, she is working as a postdoctoral fellow at the University of Padova Medical School, Dept. of Cardiac Thoracic and Vascular Sciences and Public Health and Lifelab project under the supervision of Prof. Gino Gerosa, and her current interests are to decellularize scaffold of whole porcine heart and to apply hiPSCs derived cardiomyocytes to recellularized the cardiac ECM.

Collection Overview

Biomaterials are substances applied in various fields of medicines that are used to stay in constant contact with body tissues. Tooth filling is considered to be the most practiced example where most people first encounter biomaterials. The other most delicate examples like cardiac repair with heart valves, and joint replacements.

Various categories of biomaterials have been successfully developed. They are used for more than a generation. First-generation biomaterials largely depended on being inert, or relatively inert, with minimal tissue response.

Despite the wide application and its usefulness in human health, nonspecific host immune response is always a challenge to encounter which are prone to infections. Modern biomaterials science provides a large array of biomaterial designs and surface modifications that modulate the host–material interactions to prevent an aggressive foreign-body response and at the same time avoid bacterial colonization. Furthermore, the use of biological motives in the new generations of biomaterials may elicit a specific immune response. Our special issue will cover the following main aspects of the biomaterial application and characterization and proposition of new biomaterial, which could be animal and synthetic origin with less host-tissue immune responses.

•          New methods and protocols to develop to characterize the animal, human and synthetic origin tissues

•          Interaction of cells and materials in the microenvironment

•          Materials as model systems for stem cell growth and modulation into tissue-specific cells

•          (Nano)materials and (nano)systems for therapeutic delivery

•          Biomimetic materials, including biologically inspired cell-inspired synthetic tools

Articles

Dissection and Isolation of Region-Specific Decellularized Lung Tissue
5:25

Dissection and Isolation of Region-Specific Decellularized Lung Tissue

0 Views

•

2023

•