Current Methods in Keloid Research

TOPICAL COLLECTIONS

Guest Editor

Chengcheng Deng

Dermatology Hospital, Southern Medical University

Dr. Chengcheng Deng is an Associate Professor at Dermatology Hospital, Southern Medical University. He obtained his PhD from Sun Yat-sen University Cancer Center in 2017, where he explored the function of nasopharyngeal carcinoma susceptibility genes, in the laboratory of Prof. Yixin Zeng. Dr. Deng began as an Assistant Professor to investigate the etiopathogenesis of skin fibrotic diseases in the laboratory of Prof. Bin Yang after he graduated. His research group uncovered the heterogeneity of fibroblasts in fibrotic diseases by single-cell sequencing and investigated the function of some key genes in keloid development. Dr. Deng’s current research focuses on exploring the role of fibroblasts, immune cells and vascular endothelial cells in the progress of skin wound healing and fibrotic diseases. His studies have led to multiple publications in high-impact journals, including Nature Communications, Cancer Research and Journal of Investigative dermatology.

Collection Overview

Keloids are a part of an atypical dermal wound healing and are characterized by fibroblast hyperproliferation and extra deposition of extracellular matrix (ECM). Keloids have continued their growth over the years, and they rarely regress spontaneously. A number of factors have been identified that can lead to keloid development, such as genetic predisposition, hyperactive inflammation, and immunologic conditions. Fibroblasts are the centric cell type in the pathogenesis of keloid, which leads to accumulation and inflammation of ECM. To date, the etiopathogenesis of keloids has not been completely elucidated, and radical treatments are still lacking. There are extensive research efforts focusing on exploring the molecular mechanism of keloid pathogenesis and new therapeutic strategies for keloids. The goal of this methods Collection is to summarize and demonstrate current research methods for keloids and allow for more reproducible and rigorous research related to keloid biology.