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Approaches To Study Vocal Perception And Production In Humans And Animal Models

 

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Yang Zhang

Yang Zhang

Johns Hopkins University

Dr. Yang Zhang is a postdoctoral fellow in the Department of Biomedical Engineering at Johns Hopkins University with a background in engineering, computation, and neuroscience. He obtained his PhD from Tsinghua University in China. During his PhD training, he worked vigorously in researching human speech, music, and auditory emotion processing in clinical epilepsy patients with intracranial electrodes implanted using engineering methods. He was able to collect and analyze diffusion magnetic resonance imaging (dMRI) data, resting-state magnetic resonance imaging (rsMRI) data, functional magnetic resonance imaging (fMRI) data, electrophysiology data, and electric brain stimulation data of each patient. In his postdoctoral research, he is currently working with a non-human primate model (marmosets) using his expertise in MRI, electrophysiology, and electric stimulation. His current project focuses on studying the neural basis for vocal perception and production using MRI-guided calcium imaging and multi-channel electrophysiology.

Collection Overview

A central question in auditory research is how we perceive and produce human speech and language. Understanding these mechanisms is critical to improving the diagnosis and treatment of patients suffering from speech and communication disorders such as stuttering, dysarthria, and aphasia. In animal models, species-specific vocalization is important for their social behavior. Understanding how animals perceive and produce vocalization is important for their social communication and has implications for human speech processing. 

Specifically, perception of human speech and animal vocalization includes perceiving not only linguistic information, but also non-linguistic information such as speaker identity and emotional state. Production of human speech and animal vocalization, includes vocal control, vocal feedback, and vocal communication.

This collection aims to highlight relevant techniques and approaches for studying vocal perception and production using human and animal models. In humans, these methods include but are not limited to behavior assessments, magnetic resonance imaging, functional near-infrared spectroscopy, electroencephalogram, magnetoencephalography, positron emission tomography, intracranial electroencephalography, and electric brain stimulation. In animal models, these methods include, but are not limited to behavior assessments, magnetic resonance imaging, anatomical tracing, histology, electrophysiology, optical imaging, two-photon imaging, optogenetics, and brain perturbation, such as reversible inactivation, electric stimulation, and punctate chemical lesions. 

Articles

Manufacturing Process for Non-Adhesive Super-Soft Vocal Fold Models
6:24

Manufacturing Process for Non-Adhesive Super-Soft Vocal Fold Models

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2024

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Abstracts

Amphibian ex vivo brain is a powerful tool to study the neural mechanisms of vocal production

Ayako Yamaguchi*1

1University of Utah