Neurofibromatosis Type I (NF1) is a genetic disorder caused by inactivating mutations in the tumor suppressor gene NF1. Multiple organ systems can be affected (e.g. central and peripheral nervous system, skin, heart, gastro-intestinal, bone), resulting in a wide spectrum of clinical phenotypes with unpredictable prognosis. Over the past 30 years, numerous animal models were developed to recapitulate some of these NF1-associated features. These include NF1-associated tumors (e.g., cutaneous and plexiform neurofibroma, optic glioma, malignant peripheral nerve sheath tumors), cognitive deficit (e.g., learning deficit), and cardiovascular issues (e.g., vasculopathy). The launch of this collection is an opportunity for the NF1 researcher community to share and publish method touching but not limited to: -Established NF1 in vivo model and methods. -Preparation and/or genetic modification of cells required for an NF1 animal model -Animal surgeries concerning an NF1 animal model -Animal dissection concerning an NF1 animal model